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iMosflm specifications


Unique identifier OMICS_18795
Name iMosflm
Alternative name mosflm
Software type Package/Module
Interface Graphical user interface
Restrictions to use None
Input format MTZ
Output format MTZ
Operating system Unix/Linux, Mac OS, Windows
Programming languages C, Fortran
Computer skills Medium
Version 7.2.1
Stability Stable
Maintained Yes




No version available



  • person_outline Andrew Leslie

Additional information Manual:

Publications for iMosflm

iMosflm citations


Structure guided Discovery of Dual recognition Chemibodies

Sci Rep
PMCID: 5954141
PMID: 29765112
DOI: 10.1038/s41598-018-25848-0
call_split See protocol

[…] 30% (w/v) ethylene glycol and then flash frozen in liquid nitrogen.X-ray diffraction data sets were collected at beamline 502 at Advanced Light Source (ALS) (Berkeley, CA) and processed with programs MOSFLM and SCALA in the CCP4 program suite. The structure was solved to a resolution of 2.77 Å by the molecular replacement program Phaser using a previously reported complex structure of rat DPP-IV w […]


Higher order scaffoldin assembly in Ruminococcus flavefaciens cellulosome is coordinated by a discrete cohesin dockerin interaction

Sci Rep
PMCID: 5934362
PMID: 29725056
DOI: 10.1038/s41598-018-25171-8
call_split See protocol

[…] om crystals cooled to 100 K with a Cryostream (Oxford Cryosystems Ltd). A systematic grid search was carried out on all of these crystals to select the best diffracting part of each crystal. EDNA and iMosflm were used for strategy calculation during data collection. All data sets were processed using the Fast_dp and xia2 packages, which use the programs XDS, POINTLESS and SCALA from the CCP4 suite […]


The cysteine reactive small molecule ebselen facilitates effective SOD1 maturation

Nat Commun
PMCID: 5923229
PMID: 29703933
DOI: 10.1038/s41467-018-04114-x
call_split See protocol

[…] a cryoprotectant and data were collected on I02 at Diamond Light Source and Proxima1 at SOLEIL for ebsulphur and ebselen-bound SOD1, respectively. Diffraction images were indexed and integrated using iMosflm and data were scaled using Aimless in the CCP4 suite. Rigid body refinement was performed using unmodified wild-type SOD1 from the same crystal unit cell (PDB: 2V0A). Models were manually refi […]


Targeting a Subpocket in Trypanosoma brucei Phosphodiesterase B1 (TbrPDEB1) Enables the Structure Based Discovery of Selective Inhibitors with Trypanocidal Activity

J Med Chem
PMCID: 5949723
PMID: 29672041
DOI: 10.1021/acs.jmedchem.7b01670

[…] d at Diamond Light Source (DLS; Didcot, Oxfordshire, UK) beamlines I03 and I04 at 100 K. The data sets were processed by xia2 or autoPROC, which incorporates XDS and AIMLESS, or were integrated using iMOSFLM and reduced using POINTLESS, SCALA, and TRUNCATE, all of which are part of CCP4. […]


Structural and functional studies of Spr1654: an essential aminotransferase in teichoic acid biosynthesis in Streptococcus pneumoniae

Open Biol
PMCID: 5936713
PMID: 29669826
DOI: 10.1098/rsob.170248
call_split See protocol

[…] in liquid nitrogen. Data collection was performed under cryogenic conditions (100 K) at beam line ID30B (ESRF, Grenoble, France) and beam line 14.1 (Bessy, Berlin, Germany). Data were processed with MOSFLM [] and AIMLESS [] of CCP4 suite. Data collection statistics are provided in . […]


Structural basis for the potent and selective binding of LDN 212854 to the BMP receptor kinase ALK2

PMCID: 5871398
PMID: 28918311
DOI: 10.1016/j.bone.2017.09.004
call_split See protocol

[…] Data were processed with MOSFLM and subsequently scaled using the program AIMLESS from the CCP4 suite . Initial phases were obtained by molecular replacement using the program PHASER and the structure of ALK2 (PDB ID 3H9R) […]


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iMosflm institution(s)
MRC Laboratory of Molecular Biology, Cambridge, UK
iMosflm funding source(s)
Supported by the Medical Research Council (MC_U105184325), CCP4 and the Biotechnology and Biological Sciences Research Council (BBSRC; BBF020384/1).

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