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chevron_left Bioinformatics workflows Germline reconstruction chevron_right

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IMPre specifications


Unique identifier OMICS_19163
Name IMPre
Alternative name Immune Germline Prediction
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages C, Perl
License GNU General Public License version 3.0
Computer skills Advanced
Version 1..1.0
Maintained Yes


No version available


  • person_outline Xiao Liu

Publication for Immune Germline Prediction

IMPre citations


Analyzing Immunoglobulin Repertoires

Front Immunol
PMCID: 5861150
PMID: 29593723
DOI: 10.3389/fimmu.2018.00462

[…] and mice have the most well defined ig gene loci, but a map of all allelic variants is not complete (). there have been efforts to address this with algorithms—such as tigger (), igdiscover (), impre (), and a more recent allele prediction and validation tool ()—that can be used to identify germline alleles for individual repertoires. proper identification of non-template additions […]


Next Generation Sequencing of Antibody Display Repertoires

Front Immunol
PMCID: 5810246
PMID: 29472918
DOI: 10.3389/fimmu.2018.00118

[…] such as pear (). separate analysis of heavy and light chains may be required for antibody formats such as scfv, where the presence of synthetic linkers can complicate analyses., programs such as impre (), igblast (), imgt/high v-quest (, ), and immundiversity (), which were originally developed for the analysis of b and t cell receptor repertoires, identify vh and vl germlines as well as vh […]


Combined Characterization of the Time Response of Impression Materials via Traditional and FTIR Measurements

PMCID: 5455552
DOI: 10.3390/ma8052387

[…] 912 cm−1 peak splits into two peaks at 843 and 865 cm−1. the spectrum of flexi also looks similar to both above, but closer to impri, with no above peak shoulder and splitting., for the spectrum of impre, the highest peak appears at ~1105 cm−1, which is the c–o stretching typical of ether c–o–c linkage in the 1000–1300 cm−1 range []. the second highest peak is at 2853 cm−1, due to the ch […]


Genomic Divergence during Speciation Driven by Adaptation to Altitude

Mol Biol Evol
PMCID: 3840311
PMID: 24077768
DOI: 10.1093/molbev/mst168

[…] we tried several models implemented in dadi and chose the model with the least number of parameters that was appropriate for our data; the isolation-with-migration model with population size change (impre). in this model, an ancestral population of size na undergoes an instantaneous size change to size nb at time tb. then at time ts it splits in two with size s × nb and (1 − s) × nb (where […]

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IMPre institution(s)
Beijing Genomics Institute (BGI-Shenzhen), Shenzhen, China; Merck Research Laboratories, West Point, PA, USA
IMPre funding source(s)
Supported by the Beijing Genomics Institute.

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