Consists of two sections. Imprinted gene and parent-of-origin effect database first section catalogues the current literature on imprinted genes in humans and animals. The second section catalogues current reports of parental origin of de novo mutations in humans alone. The addition of a catalogue of de novo mutations that show a parent-of-origin effect expands the scope of the database and provides a useful tool for examining parental origin trends for different types of spontaneous mutations. This section includes more than 1700 mutations, found in 59 different disorders. The 85 imprinted genes are described in 152 entries from several mammalian species. In addition, more than 300 other entries describe a range of reported parent-of-origin effects in animals.