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INDI specifications

Information


Unique identifier OMICS_05551
Name INDI
Interface Web user interface
Restrictions to use None
Input data Some generic names, synonymous names or brand names.
Computer skills Basic
Stability Stable
Maintained Yes

Maintainer


  • person_outline Assaf Gottlieb <>

Publication for INDI

INDI in publications

 (5)
PMCID: 5340788
PMID: 28316654
DOI: 10.1186/s13321-017-0200-8

[…] using integrated similarity measures including interaction profile similarities, adverse effect similarities, and target similarities []. based on the similar idea, inferring drug interactions (indi), was developed to predict cyp-related and pd-related ddi using drug chemical similarities, side effects similarities, atc (anatomical therapeutic chemical classification system) similarities, […]

PMCID: 5333429
PMID: 28249566
DOI: 10.1186/s12859-017-1546-7

[…] of our method. another approach to consider would be active learning. but, it may require a large memory and time as we are dealing with a large number of drug pairs on high dimensional space., indi is a ddi prediction tool which uses seven heterogeneous pairwise drug similarity scores based on chemical, ligands, side effects, anatomical therapeutic and chemical classification, sequence […]

PMCID: 4712252
PMID: 26446143
DOI: 10.1007/s40264-015-0352-2

[…] filtered using a method aimed to control for unmeasured confounding factors and reporting bias in a data-driven manner. we matched drug names and ae umls cuis from twosides to our dictionary., indi [] is a ddi prediction method that can infer both pharmacokinetic and pharmacodynamic interactions based on similarity to known interactions that result from a common metabolizing enzyme (cyp). […]

PMCID: 3605053
PMID: 23555229
DOI: 10.1371/journal.pcbi.1002998

[…] ; (6) text mining, connecting two drugs based on a co-occurrence scheme ; (7) twosides, a database of polypharmacy side effects for pairs of drugs mined from fda adverse event reporting system ; (8) indi, a method predicted ddis utilizing multiple drug-drug similarity measures . targets-based methods (target overlap, target distance and s-score) are better than those using indication, […]

PMCID: 3592896
PMID: 23520498
DOI: 10.1371/journal.pone.0058321

[…] but could have been found if we used other sources of interactions as a reference standard. furthermore, we further studied the false positive ddis detected by our method in test set a using the indi predictor that provides a large scale state of the art method to predict pharmacokinetic and pharmacodynamic ddis. 17 out of 49 ddis were also candidates predicted by indi suggesting agreement […]


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INDI institution(s)
The Blavatnik School of Computer Science, Tel-Aviv University, Tel-Aviv, Israel; Department of Physiology & Pharmacology, Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel; Department of Internal Medicine ‘B’, Beilinson Hospital, Rabin Medical Center, Petah-Tikva, Israel
INDI funding source(s)
Supported by the Andy Lebach Chair for Clinical Pharmacology and Toxicology, Tel-Aviv University, (Incumbent), Bikura grant from the Israel Science Foundation and James McDonnel Foundation grant, and by an Israel Science Foundation grant.

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