Innate immunity prediction software tools | Immune system data analysis
The innate immune response is a critical branch of immunity, which not only provides a first line of defence against pathogens, but also regulates and shapes subsequent adaptive responses. Innate immunity, however, can also do great harm by driving inappropriate inflammatory cascades.
Provides a model for antibody dependent cellular cytotoxicity (ADCC). ODE model can extract natural killer (NK) cells kill tumour cells from in vitro cytotoxicity data by applying perturbation methods. It is able to relate the rate at which NK cells kill in response to binding antibody with the percentage of cancer cells killed at the end of a cytotoxicity assay. This tool can predict how different initial antibody levels yield different information about the functional form of the kill rate function.
A service-based application for prediction of leucine-rich repeats (LRRs) in protein sequences. It also provides a conformational NOD-like receptor family database (NLRdb) furnishing organized information of proteins belong to NLR family.
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