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Integr8 specifications


Unique identifier OMICS_21084
Name Integr8
Restrictions to use None
Community driven No
Data access File download, Browse
User data submission Not allowed
Version 1.0
Maintained No


  • Primates
    • Homo sapiens


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Publication for Integr8

Integr8 citations


Scalable, cGMP compatible purification of extracellular vesicles carrying bioactive human heterodimeric IL 15/lactadherin complexes

J Extracell Vesicles
PMCID: 5844027
PMID: 29535850
DOI: 10.1080/20013078.2018.1442088
call_split See protocol

[…] on the mass spectrometer during the MS2 data acquisition. Spectra were searched against the human UniProt database downloaded from the European Bioinformatics Institute website (, January 2017, utilizing Proteome Discoverer 1.4 (Thermo Scientific). Up to two missed tryptic cleavage sites were allowed during the database search, while the oxidation (+15.9949 Da) of met […]


Using structural knowledge in the protein data bank to inform the search for potential host microbe protein interactions in sequence space: application to Mycobacterium tuberculosis

BMC Bioinformatics
PMCID: 5379762
PMID: 28376709
DOI: 10.1186/s12859-017-1550-y
call_split See protocol

[…] n domain) and 1 (identical domain composition). Besides the RBH approach, we separately obtained the above statistics for the predicted orthologs of MTB proteins retrieved from three other databases: Integr8 [], eggNOG [] and KEGG Orthology []. […]


The endoplasmic reticulum and casein containing vesicles contribute to milk fat globule membrane

Mol Biol Cell
PMCID: 5042581
PMID: 27535430
DOI: 10.1091/mbc.E16-06-0364

[…] ic peptides and possible N-ter protein acetylation were searched. Several databases were used: the Uniprot KB Mus musculus, C57BL6 database (49,728 entries, version March 2011 from EBI []) and the contaminant database (trypsin, keratins, etc.). The identified proteins were filtered according to the following restrictions: 1) a minimum of two different peptides was required wit […]


The MarR like protein PchR (YvmB) regulates expression of genes involved in pulcherriminic acid biosynthesis and in the initiation of sporulation in Bacillus subtilis

BMC Microbiol
PMCID: 4992311
PMID: 27542896
DOI: 10.1186/s12866-016-0807-3

[…] cation was performed with X!Tandem software (X! Tandem Sledgehammer 2013.09.01.1; against a protein database of B. subtilis 168 (downloaded to contain 4253 proteins associated to a classical proteomic contaminant database). The X!Tandem search parameters were as follows: trypsin specificity with two misse […]


Threonine 89 Is an Important Residue of Profilin 1 That Is Phosphorylatable by Protein Kinase A

PLoS One
PMCID: 4882052
PMID: 27228149
DOI: 10.1371/journal.pone.0156313

[…] verer™ software (v. 1.4.0, ThermoFisher Scientific, Waltham, MA, USA) against a UniProt human proteome database (January 2013 release) from the European Bioinformatics Institute ( The following modifications were used: static modification of cysteine (carboxyamidomethylation, +57.05 Da), variable modification of methionine (oxidation, +15.99Da) and variable modificati […]


Comparative Proteomics Reveals Important Viral Host Interactions in HCV Infected Human Liver Cells

PLoS One
PMCID: 4726516
PMID: 26808496
DOI: 10.1371/journal.pone.0147991
call_split See protocol

[…] of peptides previously selected for CID. Tandem mass spectra were searched against a combined UniProt human protein database (03/2011) from the European Bioinformatics Institute ( and the Hepatitis C virus genotype 2a (isolate JFH-1) protein sequence (UniProt Accession Q99IB8) using SEQUEST (ThermoFisher Scientific). For a fully tryptic peptide to be considered legitim […]


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Integr8 institution(s)
The EMBL Outstation–European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridge, UK; Swiss Institute of Bioinformatics, CMU, Geneva, Switzerland; RZPD Deutsches Ressourcenzentrum fur Genomforschung GmbH, Berlin, Germany; Laboratoire de Biométrie et Biologie Evolutive, UMR CNRS 5558 Université Lyon 1, Lyon, France; BIOBASE GmbH, Wolfenbuttel, Germany
Integr8 funding source(s)
Supported by the award of grant number QLRICT-2001000015 from the European Union under the RTD program ‘Quality of Life and Management of Living Resources’.

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