integrated flux-balance analysis specifications


Unique identifier OMICS_16916
Name integrated flux-balance analysis
Software type Framework/Library
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages MATLAB
Computer skills Advanced
Stability Stable
Maintained Yes




No version available


  • person_outline Markus Covert

Publication for integrated flux-balance analysis

integrated flux-balance analysis citations


Which sets of elementary flux modes form thermodynamically feasible flux distributions?

PMCID: 4949704
PMID: 26940826
DOI: 10.1111/febs.13702

[…] Thermodynamic constraints are often utilized to augment classical constraint‐based approaches . For instance, Hoppe et al. developed a metabolomics‐integrated flux‐balance analysis. Similarly, we developed thermodynamic EFMA (tEFMA) , a computational tool that calculates all TF EFMs in a metabolic reconstruction. tEFMA exploits the fact that, acc […]


A Systems Level Approach for Investigating Pseudomonas aeruginosa Biofilm Formation

PLoS One
PMCID: 3579789
PMID: 23451140
DOI: 10.1371/journal.pone.0057050

[…] ogen might form biofilms before it is eliminated by the antimicrobial agents which attack that essential gene. In other words, the essential gene is not a good target to treat the pathogen.Step 2: An integrated flux balance analysis and ACHR sampling approach is applied to determine the relative change of the flux distribution of individual biofilm-associated reactions upon the mutation of an esse […]

integrated flux-balance analysis institution(s)
Department of Bioengineering, Stanford University, Stanford, CA, USA; Program in Biomedical Informatics, Stanford, CA, USA
integrated flux-balance analysis funding source(s)
This work has been supported by a James H. Clark Faculty Scholarship in the Stanford School of Engineering, a Stanford Bio-X Fellowship, a Stanford Graduate Fellowship and the National Library of Medicine (grant number LM 07033).

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