An Integrated GlycoProteome Analyzer including mapping system for complex N-glycoproteomes, which combines methods for tandem mass spectrometry with a database search and algorithmic suite. I-GPA is a scoring algorithm with decoy glycopeptides, where 95 N-glycopeptides from standard α1-acid glycoprotein were identified with 0% false positives, giving the same results as manual validation. I-GPA platform could make a major breakthrough in high-throughput mapping of complex N-glycoproteomes, which can be applied to biomarker discovery and ongoing global human proteome project.

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Department of Mass Spectrometry, Korea Basic Science Institute, Ochang, Korea; Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon, Korea; Department of Biomedical Science, Cheongju University, Cheongju, Korea; Department of Chemistry, Hannam University, Daejeon, Korea; Department of Chemistry, Sogang University, Seoul, Korea; Cancer Biomarkers Development Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea; Department of Food Nutrition, Chungnam National University, Daejeon, Korea; Yonsei Proteome Research Center and Department of Integrated OMICS for Biomedical Science, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea; Department of Biochemistry, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea

Funding source(s)

This research was supported by the National Research Council of Science and Technology (CAP-15-03-KRIBB); by the Korea Health Technology R&D Project, through the Korea Health Industry Development Institute (KHIDI) funded by the Ministry of Health & Welfare, Republic of Korea (HI13C2098); and by the research program through the Korea Basic Science Institute (G35110).

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