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Knowledge of all molecular interactions that potentially take place in the cell is a key for a detailed understanding of cellular processes. Currently available interaction data, such as protein-protein interaction maps, are known to contain false positives that inevitably diminish the accuracy of network-based inferences. Interaction confidence scoring is thus a crucial intermediate step after obtaining interaction data and before using it in an interaction network-based inference approach.
(Kamburov et al;, 2012) IntScore: a web tool for confidence scoring of biological interactions. Nucleic Acids Res.