Permits users to establish a foundation for systematic reasoning over the intercellular network. iX is a comprehensive high-resolution knowledgebase of directional intercellular interactions that was text-mined from all available PubMed abstracts across a broad range of disease conditions. Interactions captured by this method include (i) direct cytokine binding or secretion events and more distant, and (ii) indirect influencing relations, scored and filtered to emphasize precision.
Gives a structured overview of the quorum-sensing (QS) oligopeptides, describing their microbial origin (species), functionality (method, result and receptor), peptide links and chemical characteristics (3D-structure-derived physicochemical properties). The chemical diversity observed within this group of QS signalling molecules can be used to develop new synthetic bio-active compounds. This database can function as a useful tool to justify peptide choices for evaluating different responses or to study quantitative structure–property relationships (QSPRs) of these QS molecules.
A specialized repository of quorum sensing signaling molecules (QSSMs) in prokaryotes. SigMol harbors information on QSSMs pertaining to different quorum sensing signaling systems namely acylated homoserine lactones (AHLs), diketopiperazines (DKPs), 4-hydroxy-2-alkylquinolines (HAQs), diffusible signal factors (DSFs), autoinducer-2 (AI-2) and others. Database contains 1382 entries of 182 unique signaling molecules from 215 organisms. It encompasses biological as well as chemical aspects of signaling molecules. Biological information includes genes, preliminary bioassays, identification assays and applications, while chemical detail comprises of IUPAC name, SMILES and structure.