Improves the detection of FLT3-internal tandem duplication (ITD) of varying length, position and at low allelic burden. ITDseek is a FLT3-ITD detection algorithm that detects most false negatives (97 % of simulated samples) of Pindel, GATK and Samtools. It specifically searches for any soft-clipping points in primary alignments and correlates them with any corresponding secondary alignments for ITD identification. ITDseek identifies such ITD by comparing points of soft-clipping in sequencing read pairs.
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