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Provides the biomedical community with a unified point of access to mutant mice and rich collection of related emerging and existing mouse phenotype data. IMPC mouse clinics worldwide follow rigorous highly structured and standardized protocols for the experimentation, collection and dissemination of data. Dedicated 'data wranglers' work with each phenotyping center to collate data and perform quality control of data. An automated statistical analysis pipeline has been developed to identify knockout strains with a significant change in the phenotype parameters. Annotation with biomedical ontologies allows biologists and clinicians to easily find mouse strains with phenotypic traits relevant to their research. Data integration with other resources will provide insights into mammalian gene function and human disease.

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IMPC classification

  • Animals
    • Mus musculus

IMPC specifications

Restrictions to use:
None
License:
Apache License version 2.0
Version:
4.3
Database management system:
MySQL
Data access:
Web user interface

IMPC support

Documentation

Maintainer

Credits

Publications

  • (Koscielny et al., 2014) The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Nucleic acids research.
    PMID: 24194600
  • (Brown et al., 2016) A bioimage informatics platform for high-throughput embryo phenotyping. Briefings in Bioinformatics.
    PMID: 27742664

Institution(s)

MRC Harwell Institute, Harwell Campus, Oxfordshire, UK

Funding source(s)

The National Institutes of Health (grant number 1 U54 HG006370-01); Medical Research Council Strategic Award

Link to literature

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