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International Mouse Phenotyping Consortium IMPC

Online

Alternative name: The International Knockout Mouse Consortium (IKMC)

Provides the biomedical community with a unified point of access to mutant mice and rich collection of related emerging and existing mouse phenotype data. IMPC mouse clinics worldwide follow rigorous highly structured and standardized protocols for the experimentation, collection and dissemination of data. Dedicated 'data wranglers' work with each phenotyping center to collate data and perform quality control of data. An automated statistical analysis pipeline has been developed to identify knockout strains with a significant change in the phenotype parameters. Annotation with biomedical ontologies allows biologists and clinicians to easily find mouse strains with phenotypic traits relevant to their research. Data integration with other resources will provide insights into mammalian gene function and human disease.

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IMPC classification

  • Animals
    • Mus musculus

IMPC specifications

Restrictions to use:
None
Community driven:
No
User data submission:
Not allowed
Maintained:
Yes
Database management system:
PostgreSQL
Data access:
Browse
Version:
4.3

IMPC support

Documentation

Maintainers

  • Gautier Koscielny <>
  • William Skarnes <>
  • Martin Ringwald <>

Additional information

http://www.mousephenotype.org/objectives-and-background

Credits

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Publications

Institution(s)

The Jackson Laboratory, Bar Harbor, ME, USA; The Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK; LBCMCP, UMR 5088 CNRS, Université Paul Sabatier Toulouse III, France; UCL Cancer Institute, University College London, London, UK; European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK; Manitoba Institute of Cell Biology, Winnipeg, MB, Canada; Helmholtz Zentrum Muenchen - German Research Center for Environmental Health, Neuherberg, Germany; MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK

Funding source(s)

Supported by European Commission: Project number 223592; National Institutes of Health, National Human Genome Research Institute: Grant number HG004074.

Link to literature

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