1 - 4 of 4 results


star_border star_border star_border star_border star_border
star star star star star
A method to map DNA methylation data from bisulfite sequencing approaches to CpG sites measured with the widely used Illumina methylation bead-array platforms. Correlations and median absolute deviations support the validity of using bisulfite sequencing data in combination with Illumina bead-array methylation data. The methyLiftover utility will enhance the field of epigenomic research by expanding the comparability of DNA methylation data in the absence of the common Illumina 450K methylation data. The methyLiftover tool contains functions to subset and map WGBS and RRBS data to the CpG sites specific to the Illumina 450K array, both individually and as a whole directory, and create merged data sets from two user defined methylation data files (e.g. Illumina 850K annotation).


A web tool for the detection of significant enrichment and depletion of combinations of annotations is presented. Annotation-Modules accepts 12 different input IDs, allows free selection of the reference genes and the upload of pre-annotated gene lists. It offers an improvement over the current tools in two critical aspects. First, the underlying annotation database implements features from many different fields like gene regulation and expression, sequence properties, evolution and conservation, genomic localization and functional categories-resulting in about 60 different annotation features. Second, it examines not only single annotations but also all the combinations, which is important to gain insight into the interplay of different mechanisms in the analyzed biological system.