i-COMS | interprotein COrrelated Mutations Server

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A web application to calculate correlated mutations between proteins. I-COMS allows to estimate covariation between residues of different proteins by four different covariation methods. It provides a graphical and interactive output that helps compare results obtained using different methods. I-COMS automatically builds the required MSA for the calculation and produces a rich visualization of either intraprotein and/or interprotein covariating positions in a circos representation. Furthermore, comparison between any two methods is available as well as the overlap between any or all four methodologies.

i-COMS specifications

Unique identifier:: OMICS_08859
Interface:: Web user interface
Programming languages:: C, C++, Java, Javascript, Perl, PHP, Python
Stability:: Stable

Name:: interprotein COrrelated Mutations Server
Restrictions to use:: None
Computer skills:: Basic
Maintained:: Yes

i-COMS support

Maintainer

Cristina Marino-Buslje <>

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Credits

Publications

(Iserte et al., 2015) I-COMS: Interprotein-COrrelated Mutations Server. Nucleic Acids Res.
PMID: 26032772 DOI: 10.1093/nar/gkv572

Institution(s)

Fundación Instituto Leloir Av Patricias Argentinas, Buenos Aires, Argentina

Funding source(s)

CONICET; Leloir Institute Foundation (FIL)

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