IntFOLD statistics

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Citations per year

Number of citations per year for the bioinformatics software tool IntFOLD

Tool usage distribution map

This map represents all the scientific publications referring to IntFOLD per scientific context
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Associated diseases

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Popular tool citations

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IntFOLD specifications


Unique identifier OMICS_03619
Name IntFOLD
Interface Web user interface
Restrictions to use None
Input data An amino acid sequence for the target protein. Users may optionally provide a name for their protein sequence, their email address and alternative 3D models of their protein, for direct comparison and quality assessment.
Output data The output is presented as a simple table that summarizes all prediction data graphically through thumbnail images of plots and annotated 3D models.
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline Liam J. McGuffin

Publications for IntFOLD

IntFOLD citations


Functional analysis of Plasmodium falciparum subpopulations associated with artemisinin resistance in Cambodia

Malar J
PMCID: 5735551
PMID: 29258508
DOI: 10.1186/s12936-017-2140-1

[…] Models were built using four independent structure prediction servers, IntFOLD [], Phyre2 [], RaptorX [] and LOMETS []. For each model, the top model from each of the four servers was analysed using ModFOLDclust2 [] and manually inspected, showing all models had the same […]


In Silico Characterization and Functional Validation of Cell Wall Modification Genes Imparting Waterlogging Tolerance in Maize

Bioinform Biol Insights
PMCID: 5753887
PMID: 29317803
DOI: 10.1177/1177932217747277

[…] Protein sequences were used as an input to the IntFOLD server, and best 5 structure models were selected. The top ranked model was selected that had the maximum target coverage, root mean square deviation (RMSD), and template modeling score (TM-sc […]


Current (Food) Allergenic Risk Assessment: Is It Fit for Novel Foods? Status Quo and Identification of Gaps

PMCID: 5814866
PMID: 28925060
DOI: 10.1002/mnfr.201700278

[…] utational prediction rely on modeling based on structural similarity of aa sequences between target protein and a homologous protein of known 3D structure. There are webservers available, such as the IntFOLD webserver, which provides a simple unified interface that aims to make complex protein modeling data more accessible to life scientists. Molecular modeling of three tegumental allergen‐like pr […]


Predictive and Experimental Approaches for Elucidating Protein–Protein Interactions and Quaternary Structures

Int J Mol Sci
PMCID: 5751226
PMID: 29206185
DOI: 10.3390/ijms18122623

[…] gion, which has not allowed the predicted and observed monomers to align as well as they can be aligned when truncated.In the CASP 12 experiment the McGuffin group predicted tertiary structures using IntFOLD [,,,] and other server models, then subsequently the highest scoring submitted model was further refined using the ReFOLD [] procedure. The ReFOLD refinement pipeline consists of three main pr […]


Identification of an Evolutionarily Conserved Ankyrin Domain Containing Protein, Caiap, Which Regulates Inflammasome Dependent Resistance to Bacterial Infection

Front Immunol
PMCID: 5662874
PMID: 29123523
DOI: 10.3389/fimmu.2017.01375
call_split See protocol

[…] ng the Simple Modular Architecture Research Tool (SMART), from the European Molecular Biology Laboratory (EMBL) website (, ). Finally, three-dimensional structure predictions were performed using The IntFOLD Integrated Protein Structure and Function Prediction Server () and visualized with The PyMOL Molecular Graphics System, Version 1.8 Schrödinger, LLC. The ModFOLD Quality Assessment Server (Ver […]


Biological and functional relevance of CASP predictions

PMCID: 5820171
PMID: 28975675
DOI: 10.1002/prot.25396
call_split See protocol

[…] m predicted models. Therefore, we looked for methods and servers that could predict holo sites well (Supporting Information section Tables S4 and S7). Predictions from servers Multicom‐construct and IntFOLD4 performed well for all six holo sites. These methods likely employed algorithms that benefited from ligand‐binding template information and for modeling. […]

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IntFOLD institution(s)
School of Biological Sciences, University of Reading, Reading, UK

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