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iPathwayGuide specifications


Unique identifier OMICS_05011
Name iPathwayGuide
Alternative name PathwayGuide
Software type Application/Script
Interface Graphical user interface
Restrictions to use License purchase required
Operating system Unix/Linux
License Commercial
Computer skills Medium
Stability Stable
Registration required Yes
Maintained Yes


  • Primates
    • Homo sapiens


No version available



  • person_outline PathwayGuide Team

Additional information

https://advaitabio.com/ipathwayguide-faqs/ https://advaitabio.com/ipathwayguide-tutorials/

iPathwayGuide citations


A Novel S100A8/A9 Induced Fingerprint of Mesenchymal Stem Cells associated with Enhanced Wound Healing

Sci Rep
PMCID: 5906602
PMID: 29670130
DOI: 10.1038/s41598-018-24425-9

[…] e down-regulated in S100A8/A9 treated MSCs during 6 and 24 h. To further study the pathways which are different in S100A8/A9 treated MSCs compared to control MSCs, Impact analysis was performed using iPathwayGuide and the Gene trail tool (Fig. ). Seven major pathways were uncovered in S100A8/A9 treated MSCs using topological analysis. The most significant pathways included cell motility, cell/leuk […]


Bronchoalveolar lavage (BAL) cells in idiopathic pulmonary fibrosis express a complex pro inflammatory, pro repair, angiogenic activation pattern, likely associated with macrophage iron accumulation

PLoS One
PMCID: 5896901
PMID: 29649237
DOI: 10.1371/journal.pone.0194803

[…] 88 differentially expressed genes (Table A in ).Gene Ontology and Pathway analysis of differentially expressed genes in IPF, was performed using the iPathways web resource (http://www.advaitabio.com/ipathwayguide) with the Gene Ontology (GO) Consortium database (Release 09/19/2014) and the (Kyoto Encyclopedia of Genes and Genomes, KEGG, database, Release 78.0+/06-02, Jun 16) [], using the 88 gene […]


The Plasticizer Bisphenol A Perturbs the Hepatic Epigenome: A Systems Level Analysis of the miRNome

PMCID: 5664119
PMID: 29027980
DOI: 10.3390/genes8100269

[…] × 10−3), and Inner mitochondrial membrane protein complex (q = 1.85 × 10−3) (). From the 1491 DE zebrafish genes, 1211 have human orthologs that we used as input for system level analysis in Advaita-iPathwayGuide (). In summary, 2 pathways and 2 cellular component GO terms were found to be significantly enriched (). Adherens junction (q = 0.07, ) and Oxidative phosphorylation (q = 0.07, ) were in […]


Enhanced Therapeutic Treatment of Colorectal Cancer Using Surface Modified Nanoporous Acupuncture Needles

Sci Rep
PMCID: 5635022
PMID: 29018212
DOI: 10.1038/s41598-017-11213-0

[…] Supplementary Table  shows, compared to I1, the differentially expressed genes (DEGs) in I2–I6. Pathways that were significantly changed (p < 0.05) in each group compared to I1, determined using the iPathwayGuide program, are listed in Supplementary Table . Based on statistically significant fold changes, the number of DEGs selected in I2 was 46. In I3 and I4, 21 and 69 genes were, respectively, […]


Nutrient supply affects the mRNA expression profile of the porcine skeletal muscle

BMC Genomics
PMCID: 5553784
PMID: 28797239
DOI: 10.1186/s12864-017-3986-x
call_split See protocol

[…] tion for multiple testing is achieved by using a false discovery rate approach []. We considered as differentially expressed (DE) those mRNAs displaying a |FC| > 1.5 and a q-value <0.05.Advaita Bio’s iPathwayGuide (http://www.advaitabio.com/ipathwayguide) and the Cytoscape software [] combined with the ReactomeFIViz app [] were used to infer if certain gene ontology terms and pathways are enriched […]


SGBS cells as a model of human adipocyte browning: A comprehensive comparative study with primary human white subcutaneous adipocytes

Sci Rep
PMCID: 5481408
PMID: 28642596
DOI: 10.1038/s41598-017-04369-2
call_split See protocol

[…] as performed using the heatmap.3 function from the GMD R package. The raw htseq-counts were first normalized using variance stabilizing transformation from the DESeq2 package before cluster analysis. iPathwayGuide (Advaita bioinformatics) and DAVID Bioinformatics, web-based analysis tools were further employed to identify the top biological pathways and metabolic pathways respectively. KEGG pathwa […]


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iPathwayGuide institution(s)
Advaita Corporation, Plymouth, MI, USA

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