Reconstructs very large pedigrees. IPED software is designed to handle complex pedigrees and is particularly designed to handle inbreeding and the presence of half-siblings. Also, it reconstructs pedigree only from the extant individuals. When the genotypes of the internal individuals are known, it is helpful to use all such information. For each generation, it predicts the pairwise relationships between the individuals at the current generation and creates parents for them according to their relationships.
IBM T.J. Watson Research, Yorktown Heights, New York, NY, USA; Department of Computer Science and Department of Human Genetics, University of California, Los Angeles, CA, USA; Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA, USA
IPED funding source(s)
This project was supported by National Science Foundation grants 0513612, 0731455, 0729049, 0916676, and 1065276, and National Institutes of Health grants K25-HL080079, U01-DA024417, P01-HL30568, PO1-HL28481, NIH-NIAMS 1R01AR062886-01.