Offers the access of over 2000 human samples. IRBase offers an online database of intron retention (IR). This resource permits to assess a specified intron retention event within a tissue/cell type with a gene symbol and a tissue/cell type, or assess genome-wide intron retention within an RNA-seq dataset with an RNA-seq dataset. IRBase is a part of the toolbox developed by the CNRS to study the impact of IRintron retention on gene regulation.
Bioinformatics Laboratory, Centenary Institute, Camperdown, Australia; Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA; Boston & Harvard Medical School, Boston, MA, USA; Gene & Stem Cell Therapy Program, Centenary Institute, Camperdown, Australia; CNRS, Montpellier, France; Pompeu Fabra University, UPF, Barcelona, Spain; Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Gene Regulation in Cancer Laboratory, Centenary Institute, University of Sydney, Camperdown, Australia; Université Paris Diderot, Sorbonne Paris Cité, Epigenetics and Cell Fate, CNRS, Paris, France; Catalan Institution for Research and Advanced Studies, ICREA, Barcelona, Spain; Cell and Molecular Therapies, Royal Prince Alfred Hospital, Camperdown, Australia
IRBase funding source(s)
This work was supported by the Agence Nationale de la Recherche (ANR 143683), the National Health and Medical Research Council (grant #1061906, #1080530, #1128175, #1126306), grants BIO2014-52566-R from the MINECO (Spanish Government) and FEDER funds, by AGAUR (2014-SGR1121), and by the Sandra Ibarra Foundation for Cancer (FSI2013).