IS-score pipeline

IS-score specifications

Information


Unique identifier OMICS_25465
Name IS-score
Alternative name Interface Similarity Score
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Version 1.1
Stability Stable
Maintained Yes

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Maintainer


  • person_outline Jeffrey Skolnick <>

Publication for Interface Similarity Score

IS-score IN pipelines

 (5)
2016
PMCID: 5100575
PMID: 27604871
DOI: 10.1093/nar/gkw770

[…] dna and known p53 partners for which experimental data of the complexes with p53 dbd are already available (see supplementary text s1 for details on the selected structures). we also calculated the interface similarity score (is-score), which is often used to assess models of protein-protein complexes (66,67). is-score was calculated for those models for which a reference experimental structure […]

2016
PMCID: 5100575
PMID: 27604871
DOI: 10.1093/nar/gkw770

[…] for which experimental data of the complexes with p53 dbd are already available (see supplementary text s1 for details on the selected structures). we also calculated the interface similarity score (is-score), which is often used to assess models of protein-protein complexes (66,67). is-score was calculated for those models for which a reference experimental structure of the complex […]

2016
PMCID: 5100575
PMID: 27604871
DOI: 10.1093/nar/gkw770

[…] text s1 for details on the selected structures). we also calculated the interface similarity score (is-score), which is often used to assess models of protein-protein complexes (66,67). is-score was calculated for those models for which a reference experimental structure of the complex was available. this score evaluates geometric and side-chain contact similarity of the predicted […]

2015
PMCID: 4339745
PMID: 25638036
DOI: 10.1186/s12859-015-0471-x

[…] contacts. this quantification metric is thus a reasonable one with straight forward physical interpretation in the case of capsid protein-protein interactions. we therefore attempted to compare our interface similarity score with the published q-scores for 18 t = 3 viruses in [24]., our results show that our interface similarity score largely agrees with the q-score in viral capsid […]

2015
PMCID: 4339745
PMID: 25638036
DOI: 10.1186/s12859-015-0471-x

[…] the case of capsid protein-protein interactions. we therefore attempted to compare our interface similarity score with the published q-scores for 18 t = 3 viruses in [24]., our results show that our interface similarity score largely agrees with the q-score in viral capsid protein-protein interfaces, with a high overall correlation coefficient of 0.93 (additional file 1: table s4). although […]

IS-score institution(s)
Center for the Study of Systems Biology School of Biology, Georgia Institute of Technology, Atlanta, GA, USA
IS-score funding source(s)
Supported by the National Institutes of Health Grant No. GM-48835.

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