Isoelectric point databases | Protein physicochemical properties data analysis
A protein's isoelectric point or pI corresponds to the solution pH at which its net surface charge is zero. Since the early days of solution biochemistry, the pI has been recorded and reported, and thus literature reports of pI abound.
An online database containing information about predicted isoelectric points calculated using 18 methods. Proteome-pI allows the retrieval of virtual 2D-PAGE plots and the development of customised fractions of proteome based on isoelectric point and molecular weight. The database also facilitates statistical comparisons of the various prediction methods as well as biological investigation of protein isoelectric point space in all kingdoms of life.
Catalogues comprehensively the isoelectric points (pIs) of proteins. Protein pI data were collected through scrutiny of the primary scientific literature. PIP-DB contains 5773 protein entries, each associated with either a single pI value or pI range. Each protein entry is linked to additional associated data: experimental data (stored within PIP-DB) and cross references to external data sources. Experimental data include, where available, temperature, method of analysis (IEF, cIEF, etc.), total measured molecular weight (MW), number of subunits, subunit MW, Enzyme Commission (EC) number, source organism and cellular and/or tissue location.
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