Protein-protein interactions (PPIs) are key to understanding diverse cellular processes and disease mechanisms. However, current PPI databases only provide low-resolution knowledge of PPIs, in the sense that "proteins" of currently known PPIs generally refer to "genes." It is known that alternative splicing often impacts PPI by either directly affecting protein interacting domains, or by indirectly impacting other domains, which, in turn, impacts the PPI binding. Thus, proteins translated from different isoforms of the same gene can have different interaction partners.
Source text:
(Tseng et al., 2015) IIIDB: a database for isoform-isoform interactions and isoform network modules. BMC Genomics.
A method to infer isoform-specific co-expression networks from exon-level…
A method to infer isoform-specific co-expression networks from exon-level RNA-Seq data, using large dimensional trace. SpliceNet goes beyond differentially expressed genes and infers splicing isoform…
Nowadays, many protein-protein interaction (PPI) databases are available, but…
Nowadays, many protein-protein interaction (PPI) databases are available, but the isoform level PPI prediction database has not been seen yet. IIIDB is a database for isoform-isoform interactions and…
A rich genome-wide resource of mouse networks at the isoform level, which was…
A rich genome-wide resource of mouse networks at the isoform level, which was generated using a unique framework that was originally developed to infer isoform functions. This network was built…
By using OMICtools you acknowledge that you have read and accepted the terms of the end user license agreement.