Isoform Network specifications


Unique identifier OMICS_11938
Name Isoform Network
Interface Web user interface
Restrictions to use None
Programming languages Javascript
Computer skills Basic
Stability Stable
Maintained Yes


  • Rodents
    • Mus musculus


  • person_outline Yuanfang Guan <>

Publication for Isoform Network

Isoform Network in publications

PMCID: 5915717
PMID: 29685977
DOI: 10.1098/rstb.2017.0073

[…] cis-acting binding motifs (a). epigenetic marks may be viewed in these networks as cis-acting motifs that influence the activity of splicing factors []. the second type of network is a functional isoform network. in these networks, interactions between different isoforms across genes are modelled. this is used to infer functional units according to the co-expression or shared regulation […]

PMCID: 5806117
PMID: 29356399
DOI: 10.1002/cam4.1296

[…] a splicing factor, khdrbs3. khdrbs3 changes cd44 isoform expression. we identified a novel cd44 isoform, which is regulated by khdrbs3 and enhances stemness. moreover, the sall4 ‐ khdrbs3 ‐ cd44 isoform network augments anoikis resistance. our findings provide a novel mechanism to enhance stemness in breast cancer. this study may contribute to the development of cancer therapies targeting […]

PMCID: 4756072
PMID: 26925059
DOI: 10.3389/fimmu.2016.00045

[…] surface receptor, cell type, and stimulus-specific selective and sequential activation deemed justified (). the recent phase of pkc research propounds a pkc-signaling module (, ) wherein an inter-isoform network regulates the pkc isoforms’ activity (box ; figure b). here, we propose activator- and cofactor-specific sequential activation of pkc isoforms in a spatio-temporal model wherein […]

PMCID: 3909831
PMID: 24550932
DOI: 10.3389/fgene.2014.00010

[…] 14-3-3 isoform interacts with a different number of partners with a low to moderate degree of superposition (). in figure , the size of each circle is proportional to the number of partners in each isoform network, and the thickness of the edges connecting the circles represent the jaccard similarity coefficient, which is a quantification of how much the networks overlap. formally: for two […]

PMCID: 3572099
PMID: 23418452
DOI: 10.1371/journal.pone.0055703

[…] (go) enrichment and ptms (phosphorylation, acetylation and others) in general, not specifically orientated to the 14-3-3 binding sites, as in studies by the mackintosh group , , . each polarized isoform network was characterized with respect to those parameters of their nodes, their inherent network features (motifs) and compared. the crosstalk between phosphorylation and lysine acetylation […]

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Isoform Network institution(s)
Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Institute for Systems Biology, Seattle, WA, USA; Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA; Department of Electrical Engineering and Computer Science, Ann Arbor, MI, USA
Isoform Network funding source(s)
This work is supported by grants NSF CAREER 1452656, EU-FP VII Systems Biology of Rare Disease, the University of Michigan O’Brien Kidney Translational Core Center, and by U54ES017885 to the University of Michigan M-LEEaD Center.

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