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ISOGlyP specifications


Unique identifier OMICS_19841
Name ISOGlyP
Alternative names Isoform Specific O-Glycosylation Prediction, OGPET (O-Glycosylation Prediction Electronic Tool)
Interface Web user interface
Restrictions to use None
Input data A single or multiple sequences.
Input format FASTA
Computer skills Basic
Stability Stable
Maintained Yes


  • person_outline ISOGlyP team

ISOGlyP citations


Association of CTH variant with sinusoidal obstruction syndrome in children receiving intravenous busulfan and cyclophosphamide before hematopoietic stem cell transplantation

Pharmacogenomics J
PMCID: 5817388
PMID: 27779248
DOI: 10.1038/tpj.2016.65

[…] modification sites, namely, o-galnac (mucin type) glycosylation and serine-dependent phosphorylation. further exploration of these two posttranslational modifications using glycoep and isoglyp revealed no evidence for differences in the glycocylation sites. on the other hand, for phosphorylation using disphos it is suggested that ser403 can be phosphorylated and this is lost […]


COSMC knockdown mediated aberrant O glycosylation promotes oncogenic properties in pancreatic cancer

Mol Cancer
PMCID: 4447007
PMID: 26021314
DOI: 10.1186/s12943-015-0386-1

[…] ii) are cell membrane localized (at least in carcinoma) [–] iii) and are known to promote cancer cell signaling. moreover, in silico analysis of the identified peptide protein sequences using the isoform specific o-glycosylation prediction (isoglyp) database [], revealed that these proteins are likely to be o-galnac glycosylated []. referring to the results of galnac-transferase isoform […]


The O glycomap of Lubricin, a Novel Mucin Responsible for Joint Lubrication, Identified by Site specific Glycopeptide Analysis*

PMCID: 4256492
PMID: 25187573
DOI: 10.1074/mcp.M114.040865

[…] to the stp-rich region, most of the ser/thr residues in the n-terminal region were predicted to be o-glycosylated (c). an individual ppgalnac t in vitro enzymatic specificity–based prediction tool, isoglyp (), predicted that 51% (191) of the sites were glycosylated (c and d) utilizing all ppgalnac t specificities available in the tool. this prediction is closer to the 168 detected in this study […]

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ISOGlyP funding source(s)
Supported in part by NIH Grants #5G12RR008124 from the National Center for Research Resources (NCRR)/NIH, 1R01AI070655, NCI-CA78834, and NSF-DUE0926721.

ISOGlyP review

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Warren Wakarchuk

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IsoGlyP is a very useful tool for the prediction of O-glycan sequons. We have been using it to design sites of O-Glycosylation on human proteins which are tailored to specific ppGalNAcT enzymes, and it works well. Our first publication using this approach is being submitted soon.