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Publication for IsomiRage
Chronic low dose exposure to a mixture of environmental endocrine disruptors induces microRNAs/isomiRs deregulation in mouse concomitant with intratesticular estradiol reduction
[…] s 256). Afterwards, we undertook the identification and quantification of pre-miRNAs and mature miRNAs using HTSeq script and a general feature format file (GFF) that was downloaded from miRBase v21. IsomiRage software was used for isomiRs detection and quantification. […]
Serum microRNA signatures as 'liquid biopsies' for interrogating hepatotoxic mechanisms and liver pathogenesis in human
[…] ed) separately against the HC. The results were filtered for significantly altered miRNAs applying a false discovery rate below 5 percent as described previously . For isomiR quantification we used Isomirage  to map all reads to an isomiR database derived from miRBase. The reads were converted to proportions and for each condition the predominant isomiR per miRNA was identified. Based on the r […]
miRNAs regulated by estrogens, tamoxifen, and endocrine disruptors and their downstream gene targets
[…] ated modification is adenylation, catalyzed by the adenosine deaminase (ADAR) family of enzymes (). The expression isomiRNAs is dynamic, with differences between cell types and tissues. A tool called IsomiRage http://cru.genomics.iit.it/Isomirage/ is available for profiling the miRNAs/isomiRs and corresponding differential expression patterns using Illumina next-generation sequencing datasets of s […]
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