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iStable specifications
Information
| Unique identifier | OMICS_07140 |
|---|---|
| Name | iStable |
| Interface | Web user interface |
| Restrictions to use | None |
| Programming languages | Java, PHP |
| Computer skills | Basic |
| Stability | Stable |
| Requirements |
LIBSVM
|
| Maintained | Yes |
Publication for iStable
IStable: off-the-shelf predictor integration for predicting protein stability changes.
iStable citations
(11)A case of Raine syndrome presenting with facial dysmorphy and review of literature
[…] ean sequence deviation (RMSD) of 0.3 Ao was observed between native and mutant structure, indicating changes in the loop regions of the superimposed structure. A decrease instability was predicted by iStable with a confidence score of 0.605. Furthermore, I-Mutant predicted a large decrease in protein stability due to the variant p.Ser410Thr with ΔΔG value of − 1.37 Kcal/mol (Fig. ).Fig. 3 […]
Accurate prediction of functional, structural, and stability changes in PITX2 mutations using in silico bioinformatics algorithms
[…] nse variants.The results from our molecular modeling analysis were also compared to the predictions of eight stability predictor methods (DUET, SDM, mCSM, I-mutant3.0, MUpro, iPTREE-STAB, CUPSAT, and iStable). Based on our analyses, it appears that CUPSAT performs the best of the seven methods evaluated here in predicting the effect of missense mutations on PITX2 protein stability, with SDM, DUET, […]
Fatal CTLA‐4 heterozygosity with autoimmunity and recurrent infections: a de novo mutation
[…] was not found in ESP6500 , dbSNP , 1000G , or ExAC databases. Computational predictors (SIFT , Polyphen‐2 , MutPred , PredictSNP , PROVEAN , PON‐P2 , Mutation Taster , MetaSNP , I‐Mutant Suite , and IStable ) of the effect of missense mutations assessed Tyr127Cys to be deleterious, damaging, pathogenic, and likely disease causing or to decrease protein stability (Table ). No familial segregation […]
Vermont: a multi perspective visual interactive platform for mutational analysis
[…] trategy that has gained attention is combining methods based on different paradigms and protein structural properties for the purpose of reaching a consensus on the understanding of mutation impacts. iStable and DUET are examples of such methods. Another inconvenience regarding the methods that are widely used in the study of a mutation’s impact is the lack of interpretability.Authors from the men […]
Functional analysis implicating the SNP rs61552325 in ERBB2 as an effector for androgen insensitive prostate cancer cell invasion
[…] The stability and pathogenicity of ERBB2 were predicted using four tools I-Mutant Suite [–], iStable [], PolyPhen-2 [] and HOIPE [], and revealed that the mutation Pro1140Ala was very damaging and decreased protein stability (Table ). Structural stability analysis performed by the I-Mutant Su […]
Structure of the homodimeric androgen receptor ligand binding domain
[…] ollowing bioinformatics programs were used to assess the impact of point mutations on the stability of monomeric versus dimeric AR-LBD conformations: CUPSAT (ref. ), SMD (ref. ), Polyphen (ref. ) and iStable (ref. ). All mutations were in addition visually inspected using Pymol. Folding RaCe (ref. ) was used to predict the changes in folding rates upon mutation. […]
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