iStable

[…] sequence deviation (rmsd) of 0.3 ao was observed between native and mutant structure, indicating changes in the loop regions of the superimposed structure. a decrease instability was predicted by istable with a confidence score of 0.605. furthermore, i-mutant predicted a large decrease in protein stability due to the variant p.ser410thr with δδg value of − 1.37 kcal/mol (fig. ).fig. 3, […]

[…] of pitx2, sequence in fasta format was obtained from ncbi database (np_001191327.1)., eight different protein stability programs (duet, sdm, mcsm i-mutant3.0, mupro, iptree-stab, cupsat, and istable) were used to predict the effects of missense mutations on the stability of pitx2 protein. duet is a web server that uses integrated computational approach to predict effect of missense […]

[…] polymorphism plays a central role in the mechanism of metastasis for androgen-insensitive pca., the stability and pathogenicity of erbb2 were predicted using four tools i-mutant suite [–], istable [], polyphen-2 [] and hoipe [], and revealed that the mutation pro1140ala was very damaging and decreased protein stability (table ). structural stability analysis performed by the i-mutant […]

[…] bioinformatics programs were used to assess the impact of point mutations on the stability of monomeric versus dimeric ar-lbd conformations: cupsat (ref. ), smd (ref. ), polyphen (ref. ) and istable (ref. ). all mutations were in addition visually inspected using pymol. folding race (ref. ) was used to predict the changes in folding rates upon mutation., pc-3, cos-7 and hep3b cells […]

[…] variate logistic regression model with alpha-diversity as the independent variable and the probability of disease status as the response variable. the fitted values are in table , and the final model istable 1 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \u […]