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iStable specifications


Unique identifier OMICS_07140
Name iStable
Interface Web user interface
Restrictions to use None
Programming languages Java, PHP
Computer skills Basic
Stability Stable
Maintained Yes

Publication for iStable

iStable citations


A case of Raine syndrome presenting with facial dysmorphy and review of literature

PMCID: 5948820
PMID: 29751744
DOI: 10.1186/s12881-018-0593-x

[…] sequence deviation (rmsd) of 0.3 ao was observed between native and mutant structure, indicating changes in the loop regions of the superimposed structure. a decrease instability was predicted by istable with a confidence score of 0.605. furthermore, i-mutant predicted a large decrease in protein stability due to the variant p.ser410thr with δδg value of − 1.37 kcal/mol (fig. ).fig. 3, […]


Accurate prediction of functional, structural, and stability changes in PITX2 mutations using in silico bioinformatics algorithms

PMCID: 5903617
PMID: 29664915
DOI: 10.1371/journal.pone.0195971

[…] of pitx2, sequence in fasta format was obtained from ncbi database (np_001191327.1)., eight different protein stability programs (duet, sdm, mcsm i-mutant3.0, mupro, iptree-stab, cupsat, and istable) were used to predict the effects of missense mutations on the stability of pitx2 protein. duet is a web server that uses integrated computational approach to predict effect of missense […]


Functional analysis implicating the SNP rs61552325 in ERBB2 as an effector for androgen insensitive prostate cancer cell invasion

PMCID: 5464908
PMID: 28422721
DOI: 10.18632/oncotarget.16807

[…] polymorphism plays a central role in the mechanism of metastasis for androgen-insensitive pca., the stability and pathogenicity of erbb2 were predicted using four tools i-mutant suite [–], istable [], polyphen-2 [] and hoipe [], and revealed that the mutation pro1140ala was very damaging and decreased protein stability (table ). structural stability analysis performed by the i-mutant […]


Structure of the homodimeric androgen receptor ligand binding domain

PMCID: 5303882
PMID: 28165461
DOI: 10.1038/ncomms14388

[…] bioinformatics programs were used to assess the impact of point mutations on the stability of monomeric versus dimeric ar-lbd conformations: cupsat (ref. ), smd (ref. ), polyphen (ref. ) and istable (ref. ). all mutations were in addition visually inspected using pymol. folding race (ref. ) was used to predict the changes in folding rates upon mutation., pc-3, cos-7 and hep3b cells […]


Integrated metagenomic data analysis demonstrates that a loss of diversity in oral microbiota is associated with periodontitis

PMCID: 5310281
PMID: 28198672
DOI: 10.1186/s12864-016-3254-5

[…] variate logistic regression model with alpha-diversity as the independent variable and the probability of disease status as the response variable. the fitted values are in table , and the final model istable 1 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \u […]


Enhanced candicidal compound production by a new soil isolate Penicillium verruculosum MKH7 under submerged fermentation

PMCID: 5225592
PMID: 27938325
DOI: 10.1186/s12866-016-0713-8

[…] are given in table . regression analysis was performed to fit the response function (metabolite production) with the experimental data. the second-order polynomial equation for metabolite production istable 4 2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \ […]

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iStable institution(s)
Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan

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