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Citations per year

Number of citations per year for the bioinformatics software tool iStable

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This map represents all the scientific publications referring to iStable per scientific context
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iStable specifications


Unique identifier OMICS_07140
Name iStable
Interface Web user interface
Restrictions to use None
Programming languages Java, PHP
Computer skills Basic
Stability Stable
Maintained Yes

Publication for iStable

iStable citations


A case of Raine syndrome presenting with facial dysmorphy and review of literature

BMC Med Genet
PMCID: 5948820
PMID: 29751744
DOI: 10.1186/s12881-018-0593-x

[…] ean sequence deviation (RMSD) of 0.3 Ao was observed between native and mutant structure, indicating changes in the loop regions of the superimposed structure. A decrease instability was predicted by iStable with a confidence score of 0.605. Furthermore, I-Mutant predicted a large decrease in protein stability due to the variant p.Ser410Thr with ΔΔG value of − 1.37 Kcal/mol (Fig. ).Fig. 3 […]


Accurate prediction of functional, structural, and stability changes in PITX2 mutations using in silico bioinformatics algorithms

PLoS One
PMCID: 5903617
PMID: 29664915
DOI: 10.1371/journal.pone.0195971

[…] nse variants.The results from our molecular modeling analysis were also compared to the predictions of eight stability predictor methods (DUET, SDM, mCSM, I-mutant3.0, MUpro, iPTREE-STAB, CUPSAT, and iStable). Based on our analyses, it appears that CUPSAT performs the best of the seven methods evaluated here in predicting the effect of missense mutations on PITX2 protein stability, with SDM, DUET, […]


Fatal CTLA‐4 heterozygosity with autoimmunity and recurrent infections: a de novo mutation

PMCID: 5715409
PMID: 29225858
DOI: 10.1002/ccr3.1257

[…] was not found in ESP6500 , dbSNP , 1000G , or ExAC databases. Computational predictors (SIFT , Polyphen‐2 , MutPred , PredictSNP , PROVEAN , PON‐P2 , Mutation Taster , MetaSNP , I‐Mutant Suite , and IStable ) of the effect of missense mutations assessed Tyr127Cys to be deleterious, damaging, pathogenic, and likely disease causing or to decrease protein stability (Table ). No familial segregation […]


Vermont: a multi perspective visual interactive platform for mutational analysis

BMC Bioinformatics
PMCID: 5606220
PMID: 28929973
DOI: 10.1186/s12859-017-1789-3

[…] trategy that has gained attention is combining methods based on different paradigms and protein structural properties for the purpose of reaching a consensus on the understanding of mutation impacts. iStable and DUET are examples of such methods. Another inconvenience regarding the methods that are widely used in the study of a mutation’s impact is the lack of interpretability.Authors from the men […]


Functional analysis implicating the SNP rs61552325 in ERBB2 as an effector for androgen insensitive prostate cancer cell invasion

PMCID: 5464908
PMID: 28422721
DOI: 10.18632/oncotarget.16807

[…] The stability and pathogenicity of ERBB2 were predicted using four tools I-Mutant Suite [–], iStable [], PolyPhen-2 [] and HOIPE [], and revealed that the mutation Pro1140Ala was very damaging and decreased protein stability (Table ). Structural stability analysis performed by the I-Mutant Su […]


Structure of the homodimeric androgen receptor ligand binding domain

Nat Commun
PMCID: 5303882
PMID: 28165461
DOI: 10.1038/ncomms14388

[…] ollowing bioinformatics programs were used to assess the impact of point mutations on the stability of monomeric versus dimeric AR-LBD conformations: CUPSAT (ref. ), SMD (ref. ), Polyphen (ref. ) and iStable (ref. ). All mutations were in addition visually inspected using Pymol. Folding RaCe (ref. ) was used to predict the changes in folding rates upon mutation. […]

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iStable institution(s)
Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan

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