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Associated diseases

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iStable specifications

Information


Unique identifier OMICS_07140
Name iStable
Interface Web user interface
Restrictions to use None
Programming languages Java, PHP
Computer skills Basic
Stability Stable
Requirements
LIBSVM
Maintained Yes

Publication for iStable

iStable in publications

 (12)
PMCID: 5948820
PMID: 29751744
DOI: 10.1186/s12881-018-0593-x

[…] sequence deviation (rmsd) of 0.3 ao was observed between native and mutant structure, indicating changes in the loop regions of the superimposed structure. a decrease instability was predicted by istable with a confidence score of 0.605. furthermore, i-mutant predicted a large decrease in protein stability due to the variant p.ser410thr with δδg value of − 1.37 kcal/mol (fig. ).fig. 3, […]

PMCID: 5903617
PMID: 29664915
DOI: 10.1371/journal.pone.0195971

[…] of pitx2, sequence in fasta format was obtained from ncbi database (np_001191327.1)., eight different protein stability programs (duet, sdm, mcsm i-mutant3.0, mupro, iptree-stab, cupsat, and istable) were used to predict the effects of missense mutations on the stability of pitx2 protein. duet is a web server that uses integrated computational approach to predict effect of missense […]

PMCID: 5464908
PMID: 28422721
DOI: 10.18632/oncotarget.16807

[…] polymorphism plays a central role in the mechanism of metastasis for androgen-insensitive pca., the stability and pathogenicity of erbb2 were predicted using four tools i-mutant suite [–], istable [], polyphen-2 [] and hoipe [], and revealed that the mutation pro1140ala was very damaging and decreased protein stability (table ). structural stability analysis performed by the i-mutant […]

PMCID: 5303882
PMID: 28165461
DOI: 10.1038/ncomms14388

[…] bioinformatics programs were used to assess the impact of point mutations on the stability of monomeric versus dimeric ar-lbd conformations: cupsat (ref. ), smd (ref. ), polyphen (ref. ) and istable (ref. ). all mutations were in addition visually inspected using pymol. folding race (ref. ) was used to predict the changes in folding rates upon mutation., pc-3, cos-7 and hep3b cells […]

PMCID: 5310281
PMID: 28198672
DOI: 10.1186/s12864-016-3254-5

[…] variate logistic regression model with alpha-diversity as the independent variable and the probability of disease status as the response variable. the fitted values are in table , and the final model istable 1 \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \u […]


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iStable institution(s)
Institute of Genomics and Bioinformatics, National Chung Hsing University, Taichung, Taiwan

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