Main logo
tutorial arrow
Create your own tool library
Bookmark tools and put favorites into folders to find them easily.

ITALICS | An algorithm for normalization and DNA copy number calling for Affymetrix SNP arrays


A package based on a normalization method that estimates both biological and nonrelevant effects in an alternate, iterative manner, accurately eliminating irrelevant effects. ITALICS uses a normalization algorithm for Affymetrix SNP arrays. This method was designed for the normalization and analysis of DNA copy number and significantly outperformed other methods, such as CNAT 3.0, CNAT 4.0, CNAG and GIM, in terms of SNR and can also be used to correct for experimental artifacts due to spatial effects. This method was validated by QPCR and accurately detected the breakpoints in genomic profiles. It could therefore be used to improve the characterization of samples in genomic studies.

User report

tutorial arrow
Vote up tools and offer feedback
Give value to tools and make your expertise visible
Give your feedback on this tool
Sign up for free to join and share with the community

0 user reviews

star_border star_border star_border star_border star_border
star star star star star

0 user reviews

star_border star_border star_border star_border star_border
star star star star star

No review has been posted.


tutorial arrow
Communicate with other users
Participate in the forum to get support for using tools. Ask questions about technical specifications.
Take part in the discussion
Sign up for free to ask question and share your advices

No open topic.

ITALICS classification

ITALICS specifications

Unique identifier:
Command line interface
Operating system:
Unix/Linux, Mac OS, Windows
GNU General Public License version 2.0
Software type:
Restrictions to use:
Programming languages:
Computer skills:

ITALICS distribution


tutorial arrow
Upload and version your source code
Get a DOI for each update to improve tool traceability. Archive your releases so the community can easily visualize progress on your work.
Facilitate your tool traceability
Sign up for free to upload your code and get a DOI

No versioning.

ITALICS support



tutorial arrow
Promote your skills
Define all the tasks you managed and assign your profile the appropriate badges. Become an active member.
Promote your work
Sign up for free to badge your contributorship



Institut Curie, Service de Bioinformatique, INSERM, U900, CNRS UMR144, Institut Curie, Translational Research Department, Paris, France

By using OMICtools you acknowledge that you have read and accepted the terms of the end user license agreement.