iTOP statistics

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Associated diseases

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iTOP specifications


Unique identifier OMICS_28335
Name iTOP
Alternative name inferring the TOPology
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages R
License GNU General Public License version 2.0
Computer skills Advanced
Version 1.0.2
Stability Stable
Matrix, rmarkdown, knitr, corpcor, Rgraphviz, NMF, pcalg
Maintained Yes


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  • person_outline Lodewyk F.A. Wessels <>
  • person_outline Nanne Aben <>
  • person_outline Age Smilde <>

Publication for inferring the TOPology

iTOP in publications

PMCID: 5597136
PMID: 28952574
DOI: 10.3390/bioengineering3020012

[…] the production of a protein [,]., the process of identifying genetic interactions from measured gene expression data is referred to as reverse engineering or network inference or recovery []. inferring the topology of grns and isolating functional subnetworks are computationally challenging tasks in contemporary functional genomics, and these efforts are valuable for advancing scientific […]

PMCID: 4851174
PMID: 26821913
DOI: 10.1093/sysbio/syv118

[…] even when other methods were able to utilize thousands of loci (a)., if instead branch lengths are irrelevant for a study, *beast still outperformed other methods for a given number of loci when inferring the topology of shallow species trees (e). however, when using thousands of loci, other methods were able to outperform *beast because *beast was restricted to tens of loci., for certain […]

PMCID: 4611489
PMID: 26482106
DOI: 10.1038/srep15147

[…] in the objective space, we showed how it is possible to further study this map through component analysis and spectral methods for community detection. a further extension of the framework could be inferring the topology of the network of conditions using a multidimensional scaling approach. such computational analysis can have a great impact especially for the large fraction of microorganisms […]

PMCID: 4480582
PMID: 26040458
DOI: 10.1186/s12918-015-0170-2

[…] species that can be co-measured per cell. the approaches to explore these data have focused so far either on identifying different subpopulations of cells based on multiparametric proximities or on inferring the topology of statistical relations between the parameters for the population as a whole. however, the aim to reach each of these two goals in separate has fundamental problems. in one […]

PMCID: 4335775
PMID: 25723815
DOI: 10.1186/0717-6287-47-64

[…] relations identified in previous publications) [], (2) from transcriptional analysis of a set of knockouts or mutants [], and (3) from transcriptional time-series data of wild-type organisms []. inferring the topology of a boolean network from a set of experimental data involves two main steps: first, the experimental data (gene expression profiles or protein concentrations) must […]

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iTOP institution(s)
Division of Molecular Carcinogenesis, Oncode Institute, Netherlands Cancer Institute, Amsterdam, The Netherlands; Faculty of EEMCS, Delft University of Technology, Delft, The Netherlands; Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands; Heymans Institute, University of Groningen, Groningen, The Netherlands; Cancer Genomics Netherlands, Utrecht, The Netherlands
iTOP funding source(s)
Supported by the European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) / ERC synergy grant agreement n ◦ 319661 COMBATCANCER.

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