KD Server

Predicts binding constants (Kd) for any two proteins - if a crystal structure of their complex is available. KD Server can be used for in silico Kd predictions, as well as analysis of crystal packing contacts in protein data bank (PDB) files to assess which interfaces appear more stable and are most likely to be physiological. Protein/RNA, protein/DNA and protein/small molecule complexes can be analyzed, but with larger than usual uncertainty. Predicted Kd values are often close to experimental.