KEGG Cancer statistics

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KEGG Cancer specifications


Unique identifier OMICS_03974
Name KEGG Cancer
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes


  • Primates
    • Homo sapiens

KEGG Cancer citations


Interleukin 6 identified as an important factor in hypoxia and aldehyde dehydrogenase based gefitinib adaptive resistance in non small cell lung cancer cells

PMCID: 5588073
PMID: 28927099
DOI: 10.3892/ol.2017.6613

[…] s that exhibited high IC50 values to gefitinib, including PC9 cells co-treated with gefitinib and hypoxia and ALDH-positive PC9 cells, were screened. Mapping of common differential transcripts to the KEGG cancer signaling pathway revealed that, with the exception of candidate genes also highly expressed in low gefitinib IC50 PC9 cells, fibroblast growth factor 22, Axin2, IL-6 and Fms-related tyros […]


iCAGES: integrated CAncer GEnome Score for comprehensively prioritizing driver genes in personal cancer genomes

Genome Med
PMCID: 5180414
PMID: 28007024
DOI: 10.1186/s13073-016-0390-0

[…] servations. The remaining 6152 genes were defined as TN observations. To avoid potential false negative observations in our TN training set, we required that all TN observations not be present in the KEGG Cancer Pathway [], or be defined as Oncogenes by the UniProt database [], or be defined by the Cancer Suppressor Genes in the TSGene database ( [], o […]


Tracking Cancer Genetic Evolution using OncoTrack

Sci Rep
PMCID: 4944131
PMID: 27412732
DOI: 10.1038/srep29647

[…] ith threshold of 0.95 absolute correlation, followed by network analysis and link analysis. Functional analysis on all shortlisted genes from various analyses above were performed using DAVID and 168 KEGG cancer and metabolic pathways using XomPathways. In addition to the SPKMG based analysis, we also carried out an analysis of CNVs and SNVs using the traditional SNV and CNV calling methods implem […]


Proteomic study reveals a functional network of cancer markers in the G1 Stage of the breast cancer cell cycle

BMC Cancer
PMCID: 4182858
PMID: 25252636
DOI: 10.1186/1471-2407-14-710

[…] proteins, GoMiner/DAVID categorization returned a considerable number of proteins involved in biological processes representative of all hallmarks of cancer [, ] that matched multiple pathways in the Kegg cancer diagram, i.e., proliferation, cell cycle, apoptosis, evasion of apoptosis, failed repair of genes, insensitivity to growth factors, sustained angiogenesis, and PPAR signaling []. The list […]


Detection of Deregulated Modules Using Deregulatory Linked Path

PLoS One
PMCID: 3722188
PMID: 23894653
DOI: 10.1371/journal.pone.0070412

[…] re then mapped to the nodes of the KEGG human regulatory network (denoted as G) constructed using the method by Backes et al. . The procedure integrates all the KEGG regulatory pathways including the KEGG cancer pathways into a network, which consists of 2004 nodes (genes) and 10147 directed edges (as regulatory links). Allowing for the integrity of the links among genes, the mapping is that if on […]


Heterogeneity of tumor induced gene expression changes in the human metabolic network

Nat Biotechnol
PMCID: 3681899
PMID: 23604282
DOI: 10.1038/nbt.2530

[…] annotated in the KEGG database and the 87 KEGG metabolic pathways (). The set of 214 non-metabolic cancer/signaling genes was assembled using the following two criteria: (1) genes either from the 14 KEGG cancer or 25 KEGG signaling pathways (see ), and (2) not within any of the 87 KEGG metabolic pathways. For each gene a in each tumor sample i, the expression change ΔEai was calculated. And the m […]


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