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KEGG specifications


Unique identifier OMICS_09132
Restrictions to use None
Version 76.0
Maintained Yes


  • person_outline Kae Morishima

Publications for KEGG

KEGG citations


A Five microRNA Signature for Survival Prognosis in Pancreatic Adenocarcinoma based on TCGA Data

Sci Rep
PMCID: 5955976
PMID: 29769534
DOI: 10.1038/s41598-018-22493-5
call_split See protocol

[…] iability of the bioinformatic analysis, the overlapping target genes were identified using a Venn diagram. Using the DAVID and KOBAS online databases, the functional analysis of the GO annotation and KEGG signaling pathways were carried out. In the GO analysis, the categories included biological process (BP), cellular component (CC) and molecular function (MF) terms, and a p-value < 0.05 was regar […]


Interaction between Host MicroRNAs and the Gut Microbiota in Colorectal Cancer

PMCID: 5954203
DOI: 10.1128/mSystems.00205-17

[…] CRUSt v.1.0.0 software, we generated the predicted functional profiles of the correlated and uncorrelated bacteria by assigning pathways and enzymes using the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. A total of 25 pathways have significantly altered enrichment (two-sided Wilcoxon signed-rank test with an FDR-corrected P value of <0.05) (). Interestingly, several metabolic pathways […]


Molecular, Pathological, Radiological, and Immune Profiling of Non brainstem Pediatric High Grade Glioma from the HERBY Phase II Randomized Trial

Cancer Cell
PMCID: 5956280
PMID: 29763623
DOI: 10.1016/j.ccell.2018.04.004

[…] nalysis (GSEA) showed multiple enrichments for gene sets associated with T cell signaling and the immune response (e.g., PID_CD8_TCR_ DOWNSTREAM_PATHWAY, enrichment score = 0.594, nominal p = 0.0020; KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY, enrichment score = 0.532, nominal p = 0.0297) and inflammatory-related MAPK signaling (e.g., ST_JNK_MAPK_PATHWAY, enrichment score = 0.466, nominal p = 0.0332; […]


The extent of liver injury determines hepatocyte fate toward senescence or cancer

PMCID: 5951829
PMID: 29760381
DOI: 10.1038/s41419-018-0622-x
call_split See protocol

[…] ackage was used to perform GO enrichment analysis of different cluster genes. A corrected P-value < 0.05 was adopted as the standard for judging statistically significant enrichment of cluster genes. KEGG enrichment analysis of different cluster genes was implemented using clusterProfiler R package, and the cutoff for P-value was set at 0.05. Raw sequencing data is publically available at NCBI (GE […]


Transcriptome analysis of alcohol treated microglia reveals downregulation of beta amyloid phagocytosis

PMCID: 5952855
PMID: 29759078
DOI: 10.1186/s12974-018-1184-7

[…] hose 951 AlcInf-DEs, 885 (“Alc*TII-DEs”, region 7) are increased by alcohol only in the context of inflammation but not by alcohol or by TII alone.Fig. 3Gene Ontology analysis (DAVID) identified five KEGG pathways enriched in the 312 Alc-DE group (Additional file : Table S5A), with one of the highest categories being phagosome containing 15 transcripts (Atp6ap1, C3, Calr, Coro1a, Ctss, Cyba, Fcgr1 […]


Metabolic reprogramming of the urea cycle pathway in experimental pulmonary arterial hypertension rats induced by monocrotaline

PMCID: 5948901
PMID: 29751839
DOI: 10.1186/s12931-018-0800-5

[…] ed for multiple testing by using one-paired p value, only the urea cycle pathways were enriched with the metabolites of interest (p = 0.02).Fig. 5Figure  shows the related urea cycle pathway from the KEGG and SMPDB. Urea cycle pathway, playing a major role in PAH severity and treatment response [, ], connected five major distinguished metabolites in this study. These metabolites were AMP, 4-hydrox […]

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KEGG institution(s)
Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan
KEGG funding source(s)
National Bioscience Database Center of the Japan Science and Technology Agency (partial)

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