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KEGGgraph specifications


Unique identifier OMICS_12331
Name KEGGgraph
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages R
License GNU General Public License version 2.0
Computer skills Advanced
Version 1.40.0
Stability Stable
R(>=2.10.0), methods, KEGG.db, RColorBrewer, utils, RUnit,, graph, RBGL, Rgraphviz, hgu133plus2.db, XML(>=2.3-0), SPIA
Maintained Yes




No version available



  • person_outline Jitao David Zhang

Publication for KEGGgraph

KEGGgraph citations


Core signaling pathways in ovarian cancer stem cell revealed by integrative analysis of multi marker genomics data

PLoS One
PMCID: 5933740
PMID: 29723215
DOI: 10.1371/journal.pone.0196351

[…] geo2r was employed to get the fold change data of individual genes., to obtain the kegg signaling pathways, the “pathview” r package was employed to download kgmls of humans pathways []. then the “kegggraph” r package was used to extract nodes and edges of kegg signaling pathways from kgmls []. in total, 282 signaling pathways were collected from seven categories: metabolism, genetic […]


Mechanisms of action of Coxiella burnetii effectors inferred from host pathogen protein interactions

PLoS One
PMCID: 5703456
PMID: 29176882
DOI: 10.1371/journal.pone.0188071

[…] previously []. briefly, the enrichment of gene ontology (go) [] and kyoto encyclopedia of genes and genomes (kegg) [] pathways was calculated in r by using the bioconductor packages biomart [] and kegggraph []. the background set of proteins for the go analysis involved all constituent proteins from the human ppi network, and we used the complete go tree annotation, excluding the root […]


Temporally distinct transcriptional regulation of myocyte dedifferentiation and Myofiber growth during muscle regeneration

BMC Genomics
PMCID: 5680785
PMID: 29121865
DOI: 10.1186/s12864-017-4236-y

[…] different time points (unpaired, q-value <0.1). gene sets were defined using annotations obtained from gage v2.22.0, go.db v3.2.2, and kegg.db v3.2.2. the r package “pathview” v.1.12.0 and kegggraph v1.30.0 were used to visualize gene set expression data in the context of functional pathways [, ]., cummerbund was used to perform k-means clustering (cscluster and csclusterplot […]


Cross platform analysis of transcriptomic data identifies ageing has distinct and opposite effects on tendon in males and females

Sci Rep
PMCID: 5663855
PMID: 29089527
DOI: 10.1038/s41598-017-14650-z

[…] (figures m2–m2). gene identifiers for de genes and background universal lists were converted to entrez ids and kegg pathway analysis was completed on each gene list; results were visualized using kegggraph and pathview. kegg p-values were corrected using hypergeometric testing and significant (q < 0.05) categories are summarised in tables m1 and m2 for methods one and two respectively., […]


Inferring gene and protein interactions using PubMed citations and consensus Bayesian networks

PLoS One
PMCID: 5648141
PMID: 29049295
DOI: 10.1371/journal.pone.0186004

[…] eight random topologies from each gene group, resulting in 360 bayesian networks., the methods described in this experiment were performed using the following r packages: rismed [], keggrest [], and kegggraph []. all bayesian and consensus network generation for ds1 was done on the blue waters petascale machine at the university of illinois at urbana-champaign utilizing 1024 cray cpu-only xe6 […]


Multiple network constrained regressions expand insights into influenza vaccination responses

PMCID: 5870750
PMID: 28881994
DOI: 10.1093/bioinformatics/btx260

[…] the method of ., networks were defined for reactome, go, btm and cells by connecting all pairs of genes within each gene set. the kegg network incorporated pathway topology and was built using the kegggraph r package v1.26.0 (). immuneglobal and exponly_immuneglobal networks were obtained from immunet and edges were restricted to those with confidence of at least 0.1 (). the string network […]

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KEGGgraph institution(s)
Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
KEGGgraph funding source(s)
National Genome Research Network (grant number 01GS0864) of the German Federal Ministry of Education and Research (BMBF); International PhD program of the DKFZ.

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