Compiles driver mutations in protein kinases (PKs) with experimental evidence demonstrating their functional role. Kin-driver is a manual expert-curated database that pays special attention to activating mutations (AMs) and can serve as a validation set to develop new generation tools focused on the prediction of gain-of-function driver mutations. It also offers an easy and intuitive environment to facilitate the visualization and analysis of mutations in PKs.
Fundación Instituto Leloir, Av. Patricias Argentinas 435, Buenos Aires, Argentina; Pompeu Fabra University (UPF), Department de Tecnologies de la Informació i les Comunicacions, Barcelona, Spain; Computational Genomics Laboratory, Genetics Department, Institut de Biologia Universitat de Barcelona (IBUB), Facultat de Biologia, Breakthrough Cancer Research Unit, Dexeus University Hospital, Barcelona, Spain