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KORA specifications


Unique identifier OMICS_19311
Alternative names Kooperative Gesundheitsforschung in der Region Augsburg, KORA-gen
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes


  • person_outline Erich Wichmann
  • person_outline Rolf Holle
  • person_outline Annette Peters

Additional information


Publications for Kooperative Gesundheitsforschung in der Region Augsburg

KORA citations


Genome Wide Association Study on Immunoglobulin G Glycosylation Patterns

Front Immunol
PMCID: 5834439
PMID: 29535710
DOI: 10.3389/fimmu.2018.00277

[…] We performed a genome-wide association analysis in the discovery cohort, KORA F4. First, each phenotype (see “” for explanation) was adjusted for sex and age and regression residuals were inverse normal rank transformed to assure normal distribution. The transformed residu […]


Intrinsic disorder in the partitioning protein KorB persists after co operative complex formation with operator DNA and KorA

PMCID: 5577506
PMID: 28760886
DOI: 10.1042/BCJ20170281

[…] on function P(r). The scattering data of the complexes were also analysed in the form of a normalised Kratky plot of I(q)/I(0)](qRg)2 vs. qRg []. The match points of the partially deuterated KorB and KorA proteins were determined by plotting the square root of the forward scattering intensity (√I(0)) vs. (v/v) % D2O in the solvent. The scattering density and volumes of KorB, (NΔ150)KorB and OB for […]


Systematic tissue specific functional annotation of the human genome highlights immune related DNA elements for late onset Alzheimer’s disease

PLoS Genet
PMCID: 5546707
PMID: 28742084
DOI: 10.1371/journal.pgen.1006933

[…] are subsequently curated to identify the association peaks that potentially have pleiotropic effects for AD and PD.There is a moderate overlap of control samples between IGAP AD GWAS and the PD GWAS (KORA controls, N~480). To account for the bias introduced by sample overlap and other confounding factors, we designed a permutation-based approach. In each permutation step, we shuffle the annotation […]


Genetic variants including markers from the exome chip and metabolite traits of type 2 diabetes

Sci Rep
PMCID: 5519666
PMID: 28729637
DOI: 10.1038/s41598-017-06158-3

[…] netic model (per copy of the allele on the forward strand), adjusted for age at recruitment and sex. Identified SNPs with at least suggestive significance (P < 1.64 × 10−7) were replicated within the KORA study by applying the same linear models which were further adjusted for batch effects. Results for single variant analysis from EPIC-Potsdam and KORA F4 were pooled by meta-analysis using a rand […]


Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model

PMCID: 5729551
PMID: 28540928
DOI: 10.1038/npp.2017.102

[…] s as response variable, anxiety as exposure variable and sex, age, and white blood cell proportions based on constrained projection () as additional covariates to adjust for potential confounding. In KORA, sensitivity analyses were conducted with BMI, smoking, and alcohol consumption included as additional covariates. KORA F4 samples were processed on 20 96-well plates in nine batches; plate and b […]


Genome wide methylation data mirror ancestry information

PMCID: 5267476
PMID: 28149326
DOI: 10.1186/s13072-016-0108-y

[…] The longitudinal KORA study (Cooperative health research in the Region of Augsburg) consists of independent population-based subjects from the general population living in the region of Augsburg, southern Germany []. […]


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KORA institution(s)
GSF – Forschungszentrum für Umwelt und Gesundheit, Institut für Gesundheitsokonomie und Management im Gesundheitswesen, Neuherberg, Germany; GSF – Forschungszentrum für Umwelt und Gesundheit, Institut für Epidemiologie, Neuherberg, Germany
KORA funding source(s)
Supported by GSF and grants from BMBF – Federal Ministry of Education and Research (NGFN: 01GS0423, 01GS0429, 01GR0464, 01GS0485, 01GS0499, 01GS0485, 01GR0411).

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