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KOSMOS specifications


Unique identifier OMICS_15279
Interface Web user interface
Restrictions to use None
Input data A PDB ID, a PDB file.
Output data The dynamic motions of macromolecule (in Jmol Plugin), the reference information, the linking matrix plot, the B-factor plot.
Programming languages Javascript, PHP
Database management system MySQL
License GNU General Public License version 3.0
Computer skills Basic
Version 3.0
Stability Stable
Maintained Yes



  • person_outline Moon Ki Kim <>

Publication for KOSMOS

KOSMOS in publications

PMCID: 5636086
PMID: 29020017
DOI: 10.1371/journal.pone.0185658

[…] by interpolating the distance between two end-point conformations of a target protein [–]. this transition pathway generation technique was already implemented on an online morph server called kosmos []. the mixed elastic network model (menm) was also developed to study large-scale conformational transitions []. in the menm method, the boltzmann-weighted go potentials for the end-point […]

PMCID: 4970668
PMID: 27483005
DOI: 10.1371/journal.pone.0159528

[…] from eni was validated using overlap values that were obtained by comparison with the results from nma., matlab codes for both mwcenm and eni are available for download on the online morph server kosmos (http://bioengineering.skku.ac.kr/kosmos)[]., the overlap value is widely used as a measure of similarity between the direction of conformational change and the direction given by normal mode. […]

PMCID: 4849799
PMID: 27124275
DOI: 10.1371/journal.pcbi.1004619

[…] the current conformation and the target conformation in a way that allows full flexibility and enables the protein to move around high-energy barriers, rather than over them, resulting in the mep. kosmos [] is another online morph server that, in addition to offering nma for nucleic acids, proteins, and their complexes, also generates plausible transition pathways by optimizing […]

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KOSMOS institution(s)
Department of Nano Science and Technology, Sungkyunkwan University, Cheoncheon-dong, Jangan-gu, Suwon, Korea; School of Mechanical Engineering, Sungkyunkwan University, Cheoncheon-dong, Jangan-gu, Suwon, Korea
KOSMOS funding source(s)
This work was supported by the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (R33-10079, 2011-0014584) and by the Faculty Research Funds from Sungkyunkwan University.

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