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KUPKB specifications


Unique identifier OMICS_27448
Alternative name Kidney & Urinary Pathway Knowledge Base
Restrictions to use None
Database management system SPARQL
Community driven No
Data access Browse
User data submission Allowed
Maintained Yes


  • person_outline Joost Schantra
  • person_outline Julie Klein

Publication for Kidney & Urinary Pathway Knowledge Base

KUPKB citations


Systems biology combining human and animal data miRNA and mRNA data identifies new targets in ureteropelvic junction obstruction

BMC Syst Biol
PMCID: 5333413
PMID: 28249581
DOI: 10.1186/s12918-017-0411-7

[…] E3 ubiquitin-protein ligase DTX4 by let-7a. Although E3 ubiquitin-protein ligase DTX4 has not yet been found associated to obstructive nephropathy, using the Kidney & Urinary Pathway Knowledge Base (KUPKB [],) we observed that it has been found to be induced in models of polycystic kidney disease [, ] and in a lupus nephritis model []. Furthermore, DTX4 is a member of Notch Signaling non-canonica […]


Establishment of a integrative multi omics expression database CKDdb in the context of chronic kidney disease (CKD)

Sci Rep
PMCID: 5227717
PMID: 28079125
DOI: 10.1038/srep40367

[…] re only focused in one or maximum two ‘omic platforms, lacking a multi-omics database that unifies the bulk of the scattered single ‘omics repositories. The Kidney and Urinary Pathway Knowledge Base (KUPKB) gave the first step to fill this gap, mining and collecting information of about 220 data sets across miRNA, mRNA, protein and metabolites in urine and kidney tissues. Nevertheless, KUPKB only […]


Populous: a tool for building OWL ontologies from templates

BMC Bioinformatics
PMCID: 3471341
PMID: 22373396
DOI: 10.1186/1471-2105-13-S1-S5

[…] PO) [] describes kidney cells, their function and their anatomical locations. KUPO is being built to annotate and integrate multi-omics datasets held in the Kidney and Urinary Pathway Knowledge Base (KUPKB) [].A simple template was designed for experts from the KUP domain to capture the relationships between cell types, their anatomical location and their biological functions. The template has thr […]


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KUPKB institution(s)
Institut National de la Sante et de la Recherche Medicale, U1048, Institute of Cardiovascular and Metabolic Disease, Toulouse, France; Universite Toulouse III Paul-Sabatier, Toulouse, France; School of Computer Science, University of Manchester, Manchester, UK; Section of Histology, Center for Basic Research I, Biomedical Research Foundation of the Academy of Athens, Athens, Greece
KUPKB funding source(s)
Supported by the EU/FP7/ICT-2007.4.4 e-LICO project and by the FP7-PEOPLE-2009-IAPP program Protoclin (GA 251368), by INSERM and the Direction Regional Clinique [Centre Hospitalier Universitaire (CHU) de Toulouse, Toulouse, France)] and by INSERM and the Direction de la Recherche Medicale et Innovation (CHU de Toulouse) under the Contrat Hospitalier de Recherche Translationnelle program.

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