Predicts the calpain substrate cleavage sites from amino acid sequences. LabCaS is based on a decision fusion protocol. It is robust to the extreme imbalance in positive and negative samples in the training dataset. It was tested by employing leave-one-protein-out jack-knife cross-validation which takes one protein sequence out for testing while keeping the remaining protein sequences for training.
Department of Automation, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai, China; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, USA