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LACS specifications


Unique identifier OMICS_06816
Alternative name Linear Analysis of Chemical Shifts
Interface Web user interface
Restrictions to use None
Computer skills Basic
Stability Stable
Maintained Yes

Publication for Linear Analysis of Chemical Shifts

LACS in publications

PMCID: 5925765
PMID: 29281006
DOI: 10.1093/bioinformatics/btx785

[…] and use pine-sparky extensions to create the actual assignment labels. only after following these steps could the user carry out further analysis, such as validation of chemical shift referencing by lacs (), secondary structure determination by pecan (), analysis of chemical shifts by reference to the pacsy database () or 3 d structure determination by cs-rosetta ()., pine-sparky.2, which comes […]

PMCID: 5143449
PMID: 27927232
DOI: 10.1186/s13326-016-0057-1

[…] that corresponds closely to the nmr-star ontology described by an xml schema and owl., we have extended the nmr-star dictionary to accommodate the derived data repositories on bmrb, such as lacs validation reports [], structural annotations using pacsy [] and protein blocks [], etc., followed by translation of the dictionary to an xml schema [] (bmrb/xml schema), using the pdbx/mmcif […]

PMCID: 4861749
PMID: 27023095
DOI: 10.1007/s10858-016-0029-x

[…] h(cco)nh, and hbha(co)nh (fig. a); however, as shown in fig. b, if a corresponding bmrb entry exists, the approach can be used for one-shot assignments based entirely on 2d hsqc spectra.fig. 3, linear analysis of chemical shifts (lacs) is supported by nmrfam-sparky (two-letter-code lv); lacs detects and corrects errors in chemical shift referencing (wang et al. ). areca (assessment […]

PMCID: 2654722
PMID: 19325881
DOI: 10.1371/journal.ppat.1000351

[…] are available from the national magnetic resonance facility at madison. automatically generated peak lists from hifi were used as input to the automated assignment package suite (pistachio , lacs , and pecan . 3d 15n-edited 1h-1h noesy and 3d 13c-edited 1h-1h noesy spectra were used as input for the atnos/candid/cyana suite of programs ,,. the protein structure validation software suite […]

PMCID: 2705709
PMID: 19130299
DOI: 10.1007/s10969-008-9057-4

[…] yield reliable backbone assignments for more than 90% of the amino acid residues and reliable side chain assignments with greater than 75% completeness. the assigned data are then run through the lacs [] (linear analysis of chemical shifts) software, which corrects possible referencing problems and identifies assignment outliers. the software package pecan [] (protein energetic conformational […]

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LACS institution(s)
National Magnetics Resonance Facility at Madison, Biochemistry Department, University of Wisconsin-Madison, Madison, WI, USA

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