LALIGN statistics

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Citations per year

Number of citations per year for the bioinformatics software tool LALIGN

Tool usage distribution map

This map represents all the scientific publications referring to LALIGN per scientific context
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Associated diseases


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LALIGN specifications


Unique identifier OMICS_15830
Interface Web user interface
Restrictions to use None
Input data A query sequence
Programming languages C
Computer skills Basic
Stability Stable
Maintained Yes

LALIGN citations


Effects of Mutations and Ligands on the Thermostability of the l Arginine/Agmatine Antiporter AdiC and Deduced Insights into Ligand Binding of Human l Type Amino Acid Transporters

Int J Mol Sci
PMCID: 5877779
PMID: 29558430
DOI: 10.3390/ijms19030918

[…] The amino acid sequence identity and similarity analyses were carried out with LALIGN ( by applying local alignment method using default settings, i.e., BLOSUM50 scoring matrix, 3 as number of reported sub-alignments, 10.0 as […]


Characterization of thiol‐based redox modifications of Brassica napus SNF1‐related protein kinase 2.6‐2C

FEBS Open Bio
PMCID: 5881534
PMID: 29632815
DOI: 10.1002/2211-5463.12401
call_split See protocol

[…] e retrieved according to previous studies , , , , . Sequences were aligned by ClustalW , and the conserved domains were identified as previously described . Sequence identity was calculated using the LALIGN program ( Protein tertiary structure was predicted using the RaptorX structure prediction server ( , and the tem […]


Pseudomonas rhizophila S211, a New Plant Growth Promoting Rhizobacterium with Potential in Pesticide Bioremediation

Front Microbiol
PMCID: 5829100
PMID: 29527191
DOI: 10.3389/fmicb.2018.00034

[…] Identification of closely related strains to S211 was performed based on Basic Local Alignment Search Tool (BLAST) searches. 16S rRNA gene sequences were aligned with T-Coffee (v11.00.8cbe486) using Lalign_pair and slow_pair alignments (Weng et al., ). The phylogenetic tree was reconstructed using the bayesian inference method implemented in the MrBayes program (v3.2.3). The number of substitutio […]


The SCO4117 ECF Sigma Factor Pleiotropically Controls Secondary Metabolism and Morphogenesis in Streptomyces coelicolor

Front Microbiol
PMCID: 5826349
PMID: 29515563
DOI: 10.3389/fmicb.2018.00312
call_split See protocol

[…] vidans), SAV_3491 (S. avermitilis), SVEN15_3779 (S. venezuelae), SGR_3904 (S. griseus), and SCLAV_3143/ SCLAV_3144 (S. clavuligerus). Amino acid similarities were estimated using the software package Lalign ( […]


In vitro and in vivo characterization of three Cellvibrio japonicus glycoside hydrolase family 5 members reveals potent xyloglucan backbone cleaving functions

Biotechnol Biofuels
PMCID: 5816542
PMID: 29467823
DOI: 10.1186/s13068-018-1039-6

[…] molecular replacement using Phaser [] using residues 138–500 of PDB entry 3zmr as the search model [], which align to residues 106–464 of CjGH5D, with which they share 38% identity (using the program lalign from the FASTA package []). The structure was built automatically using Buccaneer [] and refined using cycles of manual model rebuilding using Coot [] followed by refinement with REFMAC [], inc […]


Adrenergic Agonists Bind to Adrenergic Receptor Like Regions of the Mu Opioid Receptor, Enhancing Morphine and Methionine Enkephalin Binding: A New Approach to “Biased Opioids”?

Int J Mol Sci
PMCID: 5796218
PMID: 29342106
DOI: 10.3390/ijms19010272

[…] of similarity. A variety of human α and β adrenergic receptor and human opioid receptor sequences were identified in the UniProt database (Available online: These were compared using LALIGN (Available online:, BLOSSUM80, local search, all parameters set to default values []. […]

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LALIGN institution(s)
Department of Computer Science, Michigan Technological University, Houghton, MI, USA; Department of Computer Science, The Pennsylvania State University, University Park, PA, USA
LALIGN funding source(s)
This work was supported by Grant R01 LM05110 form the National Library of Medicine.

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