LAS specifications

Information


Unique identifier OMICS_15256
Name LAS
Alternative name Large Average Submatrices
Software type Package/Module
Interface Command line interface, Graphical user interface
Restrictions to use None
Operating system Unix/Linux, Mac OS, Windows
Programming languages Java, MATLAB
Computer skills Advanced
Stability Stable
Maintained Yes

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Versioning


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Documentation


Maintainer


  • person_outline Andrey Shabalin

Publication for Large Average Submatrices

LAS citation

library_books

Network analysis identifies chromosome intermingling regions as regulatory hotspots for transcription

2017
Proc Natl Acad Sci U S A
PMCID: 5748172
PMID: 29229825
DOI: 10.1073/pnas.1708028115

[…] atures and thus might be coregulated by shared regulatory factors and epigenetic marks. Our method consists of four steps outlined in : (i) identification of highly interacting domains by determining large average submatrices in interchromosomal Hi-C maps, (ii) superimposing regulatory marks on the interacting domains, (iii) construction of a network of interacting regions with edges weighted by t […]

LAS institution(s)
Department of Statistics and Operations Research, University of North Carolina, Chapel Hill, NC, USA; Department of Biology, University of North Carolina, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA; Department of Genetics, University of North Carolina, Chapel Hill, NC, USA; Department of Pathology, University of North Carolina, Chapel Hill, NC, USA
LAS funding source(s)
Supported in part by National Institutes of Health Grant P42 ES005948 and R01 AA016258, by the NCI Breast SPORE program to UNC-CH (P50-CA58223-09A1), by the V Foundation for Cancer Research, and by the Breast Cancer Research Foundation.

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