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LEGO specifications

Information


Unique identifier OMICS_26177
Name LEGO
Alternative name functional Link Enrichment of Gene Ontology or gene sets
Interface Web user interface
Restrictions to use None
Input data A gene list.
Computer skills Basic
Version 2.0
Stability Stable
Maintained No

Documentation


Maintainer


This tool is not available anymore.

Additional information


http://lego.tianlab.cn/

Information


Unique identifier OMICS_26177
Name LEGO
Alternative name functional Link Enrichment of Gene Ontology or gene sets
Software type Application/Script
Interface Command line interface
Restrictions to use None
Input data A gene list.
Operating system Unix/Linux
Programming languages C, C++, Perl, R
Computer skills Advanced
Version 2.0
Stability Stable
Maintained No

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Documentation


Maintainer


This tool is not available anymore.

Additional information


http://lego.tianlab.cn/

Publication for functional Link Enrichment of Gene Ontology or gene sets

LEGO in publications

 (3)
PMCID: 5872599
PMID: 29725270
DOI: 10.1155/2018/7501851

[…] according to the impact of lncrna binding on complete mrna molecules. the gene ontology (go) enrichment of dysregulated mrnas predicted to be regulated by lncrnas was analyzed by an integrated functional link enrichment of gene ontology or gene sets (http://lego.blueowl.cn/)., the t lymphocyte cell line 6t-cem (atcc, manassas, va, usa) was stimulated with 5% cigarette smoke extract (cse) […]

PMCID: 5756345
PMID: 29304754
DOI: 10.1186/s12864-017-4423-x

[…] change value to detect pathways with significant expression changes., dong et al. [] adopted a similar approach to ganpa and developed a new tool for over-representation analysis (ora) called "functional link enrichment of gene ontology or gene sets" (lego). the main differences between ora and fcs are: 1) fcs uses profiles of gene expression values, whereas ora only considers the genes […]

PMCID: 5423614
PMID: 28486531
DOI: 10.1371/journal.pone.0176950

[…] with the proposed method ranked the kegg pathways with the ko gene similarly or higher than the gene list of the classical approach when combined with the methods including ora [, ], spia [], and lego []. we applied the three methods ora, spia, and lego, to show that the comparison with the classical approach is not favoring a particular pathway analysis method. we also show that the proposed […]


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LEGO institution(s)
State Key Laboratory of Genetic Engineering, Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center of Genetics and Development, Department of Biostatistics and Computational Biology, School of Life Sciences, Fudan University, Shanghai, China; Children’s Hospital of Fudan University, Shanghai, China
LEGO funding source(s)
Supported by National Basic Research Program of China [2012CB316505, 2010CB529505]; the National Natural Science Foundation of China [30971643, 31071113, 91231116]; the Specialized Research Fund for the Doctoral Program of Higher Education of China [20120071110018]; the Innovation Program of Shanghai Municipal Education Commission [13ZZ006]; the National Institutes of Health (grant D43TW007887).

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