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LICORN specifications


Unique identifier OMICS_32448
Alternative name Learning co-operative regulation networks
Software type Application/Script
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Computer skills Advanced
Stability No
Maintained No


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Publication for Learning co-operative regulation networks

LICORN citations


Levosimendan in patients with left ventricular dysfunction undergoing cardiac surgery: a meta analysis and trial sequential analysis of randomized trials

Sci Rep
PMCID: 5958056
PMID: 29773835
DOI: 10.1038/s41598-018-26206-w

[…] s among LVD patients undergoing cardiac surgery,. However, most trials were small, single-center studies without robust evidence. The 3 recent large randomized clinical trials (LEVO-CTS, CHEETAH, and LICORN) provided new evidence. None of these 3 trials indicated that levosimendan had benefits with respect to clinical outcomes, which was consistent with our analysis–.There are many possible reason […]


Levosimendan in patients with low ejection fraction undergoing cardiac surgery

PMCID: 5907614
PMID: 29681959
DOI: 10.5114/kitp.2018.74673

[…] ascending aorta and aortic valve and coronary artery bypass grafting (CABG). He remained in the ICU for 27 days; ultimately, he was discharged home.Another multicenter study, dubbed with the acronym LICORN, was conducted in 13 hospitals in France to assess the efficacy of levosimendan in preventing low cardiac output syndrome after CABG []. Levosimendan was administered after anesthesia, dosed at […]


Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure

PMCID: 5888146
PMID: 29479665
DOI: 10.1111/aas.13089

[…] interpretations of the findings in the conventional meta‐analysis. None of our other predefined patient‐important outcome measures have been assessed. In the recently published LEVO‐CTS, CHEETAH, and LICORN trials, , no difference in outcome between levosimendan and placebo in patients undergoing planned cardiac surgery was found. Of note, levosimendan was studied as a second‐line inotropic agent […]


Time course transcriptome analysis of human cellular reprogramming from multiple cell types reveals the drastic change occurs between the mid phase and the late phase

BMC Genomics
PMCID: 5753469
PMID: 29298685
DOI: 10.1186/s12864-017-4389-8
call_split See protocol

[…] ing, we applied the CoRegNet package [] to infer the activity of transcription factor (TF) in the reprogramming process. The CoRegNet infers cooperative TF network and scores TF influences with the h-LICORN algorithm by using TFs and target genes expression profiles (Fig. ) []. To reconstruct regulatory networks, we set the parameter of minCoregSupport as 0.55 due to the limitation on computationa […]


Use of Levosimendan in Cardiac Surgery: An Update After the LEVO CTS, CHEETAH, and LICORN Trials in the Light of Clinical Practice

PMCID: 5768218
PMID: 29076887
DOI: 10.1097/FJC.0000000000000551

[…] indication, and this is also supported by its benign effect on kidney function.Recently, 3 randomized, placebo-controlled, multicenter studies were published on the perioperative use of levosimendan: LICORN, CHEETAH, and LEVO-CTS. In contrast to the many preceding smaller trials which, either individually or as a whole, produced a promising image of levosimendan in perioperative settings, these la […]


Inference and interrogation of a coregulatory network in the context of lipid accumulation in Yarrowia lipolytica

NPJ Syst Biol Appl
PMCID: 5554221
PMID: 28955503
DOI: 10.1038/s41540-017-0024-1

[…] s, particularly for small sample numbers, an advantage when studying a non-conventional yeast, such as Y. lipolytica, for which few transcriptomic datasets are available.CoRegNet uses an algorithm, h-LICORN (hybrid-Learning Cooperative Regulation Network), to infer a list of GRNs from a discretized transcriptomic data set and a list of known regulators on the basis of a frequent itemset mining app […]


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LICORN institution(s)
LRI, CNRS UMR 8623, Université Paris Sud, Orsay, France; Institut Curie, CNRS UMR 144, Paris, France; Institut Curie, Service de Bioinformatique, Paris, France; IGM, CNRS UMR 8621, Université Paris-Sud, Orsay, France
LICORN funding source(s)
Supported by the CNRS, the Institut Curie, the Plan Pluri-Formation Bioinformatique et Genomique and the IFR Genome, a fellowship from the French Ministry of Foreign Affairs and a fellowship from the association Courir pour la vie, courir pour Curie.

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