LiSiCA statistics

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Citations per year

Number of citations per year for the bioinformatics software tool LiSiCA

Tool usage distribution map

This map represents all the scientific publications referring to LiSiCA per scientific context
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Associated diseases


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LiSiCA specifications


Unique identifier OMICS_24925
Name LiSiCA
Alternative name Ligand Similarity using Clique Algorithm
Software type Application/Script
Interface Command line interface
Restrictions to use None
Input data A reference and the target compound files.
Input format MOL2
Operating system Unix/Linux, Mac OS, Windows
Computer skills Advanced
Version 1.0.1
Stability Stable
Source code URL
Maintained Yes




No version available


  • person_outline Dusanka Janezic
  • person_outline Janez Konc

Publication for Ligand Similarity using Clique Algorithm

LiSiCA citations


BoBER: web interface to the base of bioisosterically exchangeable replacements

J Cheminform
PMCID: 5727005
PMID: 29234984
DOI: 10.1186/s13321-017-0251-x

[…] lead structures. We showed how the BoBER web server could be used on an inhibitor of MurF enzyme. In the future, the BoBER approach will be implemented in the ligand-based virtual screening software LiSiCA [] to enable searching databases for similar ligands not only on the basis of atom type similarity but also based on possible bioisosteric or scaffold hopping replacements. […]


Trypanocidal Effect of Isotretinoin through the Inhibition of Polyamine and Amino Acid Transporters in Trypanosoma cruzi

PLoS Negl Trop Dis
PMCID: 5371382
PMID: 28306713
DOI: 10.1371/journal.pntd.0005472

[…] earching in a database that comprises a total of 2924 worldwide commercially available drugs and nutraceuticals approved by U.S. Food and Drug Administration (FDA). This screening was performed using LiSiCA v1.0 (Ligand Similarity using Clique Algorithm) software [], and similarities were expressed using the Tanimoto coefficient []. The structural data of compounds retrieved from similarity screen […]


Ligand based virtual screening interface between PyMOL and LiSiCA

J Cheminform
PMCID: 5013575
PMID: 27606012
DOI: 10.1186/s13321-016-0157-z
call_split See protocol

[…] The general requirement for the LiSiCA plugin is an installed PyMOL program (version >1.4) with plugin support. LiSiCA software executable used by the plugin runs under Linux and Windows operating systems. The plugin uses the native […]


Direct Characterization of Transcription Elongation by RNA Polymerase I

PLoS One
PMCID: 4959687
PMID: 27455049
DOI: 10.1371/journal.pone.0159527

[…] In this experimental setup, both our measurement and the estimate by Viktorovskaya et al. [] yield an in vitro average elongation rate of 18–20 nt/s. A recent in vitro study using optical tweezers by Lisica et al. [] reported, instead, a similar average and maximum elongation rate (~32 nt/s and ~39 nt/s, respectively). Their experimental conditions differed from those used in our work in that they […]

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LiSiCA institution(s)
National Institute of Chemistry, Ljubljana, Slovenia; Faculty of Mathematics, Natural Sciences and Information Technologies, University of Primorska, Koper, Slovenia; Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia

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