Allows discovering the functional miRNA regulatory modules (FMRMs). The algorithm of Liu et al. is a method that integrates heterogeneous datasets, including expression profiles of both miRNAs and mRNAs, with or without using prior target binding information. This model is inspired by the Correspondence Latent Dirichlet Allocation (Corr-LDA), which has been used to extract the correspondence patterns from heterogeneous data. This method simultaneously identifies groups of interactive miRNAs and mRNAs, which are believed to participate in specific biological functions.
School of Computer and Information Science, University of South Australia, Mawson Lakes, SA, Australia; Centre for Cancer Biology, SA Pathology, Adelaide, SA, Australia; School of Molecular and Biomedical Science, The University of Adelaide, Adelaide, SA, Australia; Department of Medicine, The University of Adelaide, Adelaide, SA, Australia; Laboratory of Cancer Biology and Genetics, National Cancer Institute, Bethesda, MD, USA; Laboratory of Molecular Technology, NCI-FCRDC, Frederick, MD, USA
LiuEtAl2010 funding source(s)
Supported by Intramural Program, Center for Cancer Research, NIH, Bethesda, MD, USA.