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Citations per year

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LoLoPicker specifications


Unique identifier OMICS_11396
Name LoLoPicker
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages Python
Computer skills Advanced
Stability Stable
PySam, PySamstats
Maintained Yes


No version available



  • person_outline Jian Carrot-Zhang

Publication for LoLoPicker

LoLoPicker citation


A review of somatic single nucleotide variant calling algorithms for next generation sequencing data

Comput Struct Biotechnol J
PMCID: 5852328
PMID: 29552334
DOI: 10.1016/j.csbj.2018.01.003

[…] don the diploidy assumption and model joint allele frequencies (fT,fN) instead of joint genotypes (GT,GN). The allele frequency analysis approach is taken by Strelka, MuTect, LoFreq, EBCall, deepSNV, LoLoPicker, and MuSEĀ , , , , , , . Strelka's core algorithm consists of two steps. First, the posterior probabilities of VAFs in tumor and normal, noted as P(fT,fN|DT,DN), are estimated based proporti […]

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LoLoPicker institution(s)
Cancer Program, The Broad Institute of Harvard and MIT, Cambridge, MA, USA; Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Human Genetics, McGill University, Montreal, QC, Canada; Genome Quebec Innovation Centre, Montreal, QC, Canada
LoLoPicker funding source(s)
Supported by the Canadian Institutes of Health Research [grant number 77764]; by the CIHR postdoctoral fellowship; and by a Canada Research Chair in Genomics.

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