Contains easily accessible and user-friendly information about subcellular localization and levels for 5330 yeast proteins under three environmental stress conditions and two genetic perturbations. Using LoQAtE DB, users can get a profile of changes for proteins of interest as well as querying advanced intersections by either abundance changes, primary localization or localization shifts over the tested conditions. Currently, the DB hosts information on 5330 yeast proteins under three external perturbations (DTT, H2O2 and nitrogen starvation) and two genetic mutations [in the chaperonin containing TCP1 (CCT) complex and in the proteasome]. Additional conditions will be uploaded regularly. The data demonstrate hundreds of localization and abundance changes, many of which were not detected at the level of mRNA. LoQAtE is designed to allow easy navigation for non-experts in high-content microscopy and data are available for download.
Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel; Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA, USA
LoQAtE funding source(s)
Isreali Ministry of Science, the European Research Council (ERC) Starting Grant [StG 260395] and reintegration grant [IRG 239224]; EMBO Young Investigator Fellow; Recipient of an MIT International Science and Technology Initiative (MISTI)