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A web tool for genome-wide annotation of human SNPs. LS-SNP/PDB provides information useful for identifying amino-acid changing SNPs (nsSNPs) that are most likely to have an impact on biological function. The system is kept up-to-date by an automated, high-throughput build pipeline that systematically maps human nsSNPs onto Protein Data Bank structures and annotates several biologically relevant features, inferred from three-dimensional experimental structures.

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LS-SNP/PDB classification

  • Animals
    • Homo sapiens

LS-SNP/PDB specifications

Web user interface
Computer skills:
Restrictions to use:

LS-SNP/PDB support


  • Rachel Karchin <>


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Department of Bioinformatics, George Mason University, Fairfax, VA, USA; Department of Biomolecular Engineering, University of California, Santa Cruz, CA, USA; Department of Biomedical Engineering, Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD, USA

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