LTKB specifications

Information


Unique identifier OMICS_18791
Name LTKB
Alternative name Liver Toxicity Knowledge Base
Restrictions to use None
Community driven No
Data access Browse
User data submission Not allowed
Maintained Yes

Maintainer


  • person_outline Dr. Weida Tong

Additional information


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Publication for Liver Toxicity Knowledge Base

LTKB citation

library_books

Prediction models for drug induced hepatotoxicity by using weighted molecular fingerprints

2017
BMC Bioinformatics
PMCID: 5471939
PMID: 28617228
DOI: 10.1186/s12859-017-1638-4

[…] y, we focused on improving DILI prediction models using Bayesian weighted substructures and identifying frequently appearing substructures that might be key for DILI (Fig. ). First, datasets from the Liver Toxicity Knowledge Base (LTKB) and the DrugBank database were obtained and pre-processed []. We then extracted substructure feature information from 312 compounds. The weighted features were obt […]

LTKB institution(s)
Division of Systems Biology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, USA; Z-Tech Corporation, an ICF International Company at NCTR, Jefferson, AR, USA
LTKB funding source(s)
Supported by the FDA’s Critical Path Initiative, the Office of Women’s Health and the Chief Scientist Challenge Grant.

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