LW-FQZip specifications


Unique identifier OMICS_08993
Name LW-FQZip
Software type Package/Module
Interface Command line interface
Restrictions to use None
Operating system Unix/Linux
Programming languages C
Computer skills Advanced
Stability Stable
Maintained Yes


No version available


  • person_outline Zexuan Zhu

Additional information


Publications for LW-FQZip

LW-FQZip citation


Optimal compressed representation of high throughput sequence data via light assembly

Nat Commun
PMCID: 5805770
PMID: 29422526
DOI: 10.1038/s41467-017-02480-6

[…] ata set by either (i) assembling reads into long contigs, typically by a de Bruijn graph-based approach (e.g., Quip, Leon, k-Path, and KIC), or by (ii) aligning the reads to a reference genome (e.g., LW-FQZip); the reads are then encoded as simple pointers to the reference or the assembled contigs.Because both sequence mapping and assembly are computationally intensive tasks, all the above HTS com […]

LW-FQZip institution(s)
College of Computer Science and Software Engineering, Shenzhen University, Shenzhen, China; The Broad Institute, Cambridge, MA, USA; School of Computer Science, University of Birmingham, Birmingham, UK
LW-FQZip funding source(s)
This work was supported in part by the National Natural Science Foundation of China (61471246 and 61205092), Guangdong Foundation of Outstanding Young Teachers in Higher Education Institutions (Yq2013141), Shenzhen Scientific Research and Development Funding Program (JCYJ20130329115450637, KQC201108300045A and ZYC201105170243A) and Guangdong Natural Science Foundation (S2012010009545).

LW-FQZip review

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Anonymous user #383

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I tried this tool but the compression doesn't seem to be that great.

I could compress the example fastq of 31M was to 8.6M. This is exactly the same size as if you would use gzip on this file. Using bzip2 the file size is reduced even further to 7.3M.

Additionally when I tried to compress my own fastq files (human) I got he error 'error genome file size'. After solving this issue in a hard coded way, I got a buffer overflow using the LWFQZip -c command.