Implements a complete and automated method for building of B- and T-cell receptor structural models starting from their amino acid sequence alone. LYRA is based on the canonical structure method and can produce, easily and within minutes, extremely reliable models of lymphocyte receptors. It is freely available and easy to use for non-specialists. Upon submission, LYRA automatically generates alignments using ad hoc profiles, predicts the structural class of each hypervariable loop, selects the best templates in an automatic fashion, and provides within minutes a complete 3D model that can be downloaded or inspected online. Experienced users can manually select or exclude template structures according to case specific information.
Center for Biological Sequence Analysis, Technical University of Denmark, Kgs Lyngby, Denmark
LYRA funding source(s)
Argentinean National Research Council (CONICET). This study was supported in whole or in part with Federal funds from the National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN272201200010C, by Danish research council and Technical University of Denmark fundings.