A computational platform, M-path, to explore synthetic metabolic pathways including putative enzymatic reactions and compounds. M-path is an iterative random algorithm which makes efficient use of chemical and enzymatic databases to find potential synthetic metabolic pathways. M-path can readily control the search space, and perform well compared to exhaustively enumerating possible pathways. A web-based pathway viewer is also developed to check extensive metabolic pathways with evaluation scores on the basis of chemical similarities.
Organization of Advanced Science and Technology, Kobe University, Kobe, Department of Chemical Science and Engineering, Graduate School of Engineering, Kobe University, Kobe, Mitsui Knowledge Industry (MKI) Co, Osaka, MCHC R&D Synergy Center, Inc, Yokohama and Mitsubishi Chemical Group Science and Technology Research Center (MCRC) Inc, Yokohama, Japan